Several delivery strategies are employed to overcome the challenges of nucleic acid stability, cellular uptake, and tissue targeting for small nucleic acid drugs. 

Despite their therapeutic potential, small nucleic acid drugs face several significant challenges in development: 

Small nucleic acid drugs exhibit distinct features that set them apart from small molecule drugs and antibody-based therapies.

Small nucleic acid drugs exhibit distinct features that set them apart from small molecule drugs and antibody-based therapies.