[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"ApplicationsList":3,"BlogDetail77Info":39,"ProductServiceList":171,"BasicInfo":371},{"msg":4,"code":5,"data":6},"操作成功",0,[7,20,24,28,32,35],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":9,"title":10,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":11,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":12,"productService":8},null,9,"Oligonucleotide Drug Synthesis",90,[13,16],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":9,"orderNum":8,"ancestors":8,"id":14,"title":15,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":11,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},19,"Oligonucleotide Synthesis and Modifications",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":9,"orderNum":8,"ancestors":8,"id":17,"title":18,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":19,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},20,"Oligonucleotide biological evaluation platform",50,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":21,"title":22,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":23,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},14,"Gene&Genome Editing",80,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":25,"title":26,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":27,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},15,"Synthetic Biology",70,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":29,"title":30,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":31,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},16,"Antibody Drug Discovery",60,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":33,"title":34,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":19,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},17,"IVD Raw Material",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":36,"title":37,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":38,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},18,"Vaccine and Novel Therapy",40,{"msg":4,"code":5,"data":40},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":41,"categoryName":42,"title":43,"imgUrl":44,"content":45,"excerpt":46,"publishDate":47,"seoTitle":48,"seoDesc":49,"seoKeywords":50,"createDate":51,"sort":52,"relatedPostIds":53,"firstServiceProductId":54,"secondServiceProductIds":55,"relatedPost":56,"productService":118,"allSecondProductService":135,"twoSecondProductService":168},77,"RNA & Nucleic Acid Drug","What are the sgRNA-based pipelines currently in clinical stages?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F23_20260630155415A135.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F23_20260630155421A136.png\" title=\"sgRNA-based pipelines\" alt=\"sgRNA-based pipelines\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Single-guide RNA (sgRNA) is an essential element of CRISPR-based genome editing therapies. While sgRNA itself is not a standalone drug, it plays a pivotal role in directing Cas proteins to specific genetic sequences for precise editing. Several sgRNA-based pipelines have entered clinical trials, primarily targeting genetic disorders and certain complex diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Key sgRNA-Based Clinical Pipelines \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      CRISPR Therapeutics\u002FVertex Pharmaceuticals – Exa-Cel (Exagamglogene autotemcel) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Diseases: Sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: Uses sgRNA and Cas9 to disrupt the BCL11A gene in hematopoietic stem cells, reactivating fetal hemoglobin production. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Clinical Status: In Phase III clinical trials, with promising results; regulatory filings for approval were submitted in 2023. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Editas Medicine – EDIT-301 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Diseases: Sickle cell disease (SCD) and beta-thalassemia. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: Employs Cas12a (Cpf1) with sgRNA to precisely edit the HBG1\u002F2 promoters, increasing fetal hemoglobin expression. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Clinical Status: Phase I\u002FII trials are ongoing, with early safety and efficacy data showing encouraging outcomes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Intellia Therapeutics – NTLA-2001 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Disease: Transthyretin amyloidosis (ATTR). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: In vivo delivery of sgRNA and Cas9 using lipid nanoparticles (LNPs) to disrupt the TTR gene, reducing toxic transthyretin protein levels. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Clinical Status: Phase I trials have demonstrated significant reductions in serum TTR levels. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Verve Therapeutics – VERVE-101 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Disease: Hypercholesterolemia. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: Uses base-editing technology guided by sgRNA to introduce specific edits into the PCSK9 gene, lowering LDL cholesterol levels. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Clinical Status: Phase I trials are underway for patients with familial hypercholesterolemia. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Caribou Biosciences – CB-010 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Disease: B-cell non-Hodgkin lymphoma. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: sgRNA-based editing to enhance allogeneic CAR-T cell therapy by removing immune-evasion genes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●     Clinical Status: Phase I trials are ongoing, with preliminary data showing durable responses. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The sgRNA-driven clinical pipeline reflects the versatility and transformative potential of CRISPR-based therapeutics. From correcting monogenic disorders to treating complex conditions like cancer and cardiovascular diseases, these therapies are steadily progressing toward commercialization. Continued innovation in sgRNA design and delivery will further expand their therapeutic reach, offering hope for previously untreatable conditions.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","","2025-03-13 00:00:00","RNA Synthesis & Modifications—sgRNA-based pipelines currently in clinical stages","The sgRNA-driven clinical pipeline reflects the versatility and transformative potential of CRISPR-based therapeutics. From correcting monogenic disorders to treating complex conditions like cancer and cardiovascular diseases, these therapies are steadily progressing toward commercialization.","RNA Oligo, sgRNA, guide RNA, gene editing, CRISPR, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:53:03",24,"72,68,66,64,61",1,"58,59",[57,70,83,95,107],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":58,"categoryName":42,"title":59,"imgUrl":60,"content":61,"excerpt":46,"publishDate":62,"seoTitle":63,"seoDesc":64,"seoKeywords":65,"createDate":66,"sort":67,"relatedPostIds":68,"firstServiceProductId":54,"secondServiceProductIds":69,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},61,"How does GalNAc help in the delivery of small nucleic acid drugs?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F08_20260630144912A106.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F08_20260630144908A105.png\" title=\"GalNAc, drug delivery, custom RNA synthesis\" alt=\"GalNAc, drug delivery, custom RNA synthesis\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GalNAc plays a crucial role in enhancing the targeted delivery of small nucleic acid drugs, particularly for liver-targeted therapies. Here's how it works: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Specific Binding to Liver Cells: GalNAc specifically binds to the asialoglycoprotein receptors (ASGPR) that are highly expressed on hepatocytes (liver cells). This binding facilitates the selective uptake of nucleic acid drugs by liver cells, ensuring targeted delivery. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Increased Cellular Uptake: By attaching GalNAc to small nucleic acids (such as siRNA or ASOs), the drug is more efficiently internalized into liver cells via receptor-mediated endocytosis. This enhances the bioavailability of the drug in the liver. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Improved Pharmacokinetics: GalNAc conjugation increases the stability of the drug in circulation, allowing it to remain in the bloodstream longer before being cleared. This extended half-life improves the therapeutic window, increasing the drug's effectiveness. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Reduced Off-Target Effects: The liver-specific targeting of GalNAc reduces the likelihood of the drug affecting other tissues, minimizing off-target effects and systemic toxicity. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Enhanced Efficacy: The precise delivery to liver cells allows for higher local concentrations of the drug, leading to more efficient gene silencing (for RNAi drugs) or modulation (for ASOs) in liver-related diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">By directing the therapeutic nucleic acid to the liver specifically, GalNAc enables small nucleic acid drugs to achieve higher therapeutic efficacy while minimizing side effects, particularly for diseases affecting the liver. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">,\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\"> and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-26 00:00:00","RNA Synthesis & Modifications—GalNAc and small nucleic acid drug delivery","By directing the therapeutic nucleic acid to the liver specifically, GalNAc enables small nucleic acid drugs to achieve higher therapeutic efficacy while minimizing side effects, particularly for diseases affecting the liver.","RNA Modifications, siRNA, miRNA, Antisense Oligo, GalNAc, drug delivery, custom RNA synthesis","2025-04-28 17:08:09",8,"78,76,71,70,57","13,60",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":71,"categoryName":42,"title":72,"imgUrl":73,"content":74,"excerpt":46,"publishDate":75,"seoTitle":76,"seoDesc":77,"seoKeywords":78,"createDate":79,"sort":80,"relatedPostIds":81,"firstServiceProductId":54,"secondServiceProductIds":82,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},64,"How to assess the silencing effect of siRNA?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F11_20260630145425A111.png","\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F11_20260630145430A112.png\" title=\"silencing\" alt=\"silencing\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Assessing the silencing effect of \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002Fadmin\u002FGenCefe%20Biotech%20provides%20high-quality%20siRNA,%20miRNA,%20sgRNA,%20and%20custom%20RNA%20synthesis%20services.%20We%20can%20design%20and%20synthesize%20RNA%20Oligos%20of%20different%20lengths,%20different%20forms,%20and%20with%20various%20modification\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 16px;\">siRNA\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\"> is crucial to confirm its effectiveness in downregulating target gene expression. Several methods can be used to evaluate the silencing efficiency of siRNA. Below are the most common approaches: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">1. mRNA Expression Analysis (Quantitative PCR) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: Measure the mRNA levels of the target gene before and after siRNA treatment using quantitative PCR (qPCR). A decrease in mRNA levels indicates effective silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Ensure that the primers used are specific for the target gene and not other homologous genes to avoid off-target effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">2. Western Blotting \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: Western blotting detects the protein levels of the target gene. If the siRNA is effective, a significant reduction in protein expression should be observed compared to the control. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Antibodies used for detection must be highly specific to the target protein. This method can be more informative than qPCR since it measures the actual protein product. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">3. Reporter Assay (Luciferase or GFP Reporter) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: If the target gene has been fused to a reporter gene (such as luciferase or GFP), the expression of the reporter can be measured. A decrease in reporter signal indicates effective siRNA silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Reporter assays are useful for measuring the impact of siRNA on specific targets, and they are relatively easy to quantify. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4. Flow Cytometry (for Fluorescent Proteins or Surface Markers) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: If the target gene influences cell surface markers or a fluorescent protein (e.g., GFP or mCherry), flow cytometry can be used to quantify changes in expression at the single-cell level. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Flow cytometry is powerful for analyzing heterogeneous cell populations and detecting slight variations in silencing efficacy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5. RNA Sequencing (RNA-Seq) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: RNA-Seq is a high-throughput sequencing technique that can be used to evaluate changes in global gene expression profiles upon siRNA treatment. It can identify not only the target gene but also potential off-target effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: This method provides a comprehensive view but can be more expensive and requires more extensive data analysis. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">6. Quantification of Targeted mRNA by Northern Blotting \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: Northern blotting can be used to detect and quantify specific mRNA species, including any potential cleavage products of the target mRNA. A reduction in the target mRNA band indicates effective silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Although more labor-intensive than qPCR, Northern blotting can provide additional information about the size and structure of the mRNA. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">7. Cell Phenotype Analysis \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: Analyze changes in cell phenotype (e.g., morphology, proliferation, apoptosis) after siRNA treatment, particularly if the target gene plays a role in a specific cellular process. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: This can be used as a functional readout, but it is often more difficult to directly attribute changes to specific target genes without further validation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">8. ELISA (Enzyme-Linked Immunosorbent Assay) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: If the target gene produces a secreted protein (e.g., cytokines, growth factors), ELISA can quantify the protein in the culture medium to assess the effect of siRNA on secretion. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: ELISA is useful for monitoring secreted proteins, but it requires high specificity of the antibody and the availability of commercial kits for the target protein. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">9. In Vivo Validation (Animal Models) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: In animal models, siRNA is delivered systemically or locally, and silencing effects are assessed by measuring mRNA and protein expression, or phenotypic changes (e.g., tumor growth reduction, liver disease markers). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: In vivo experiments are more complex and require ethical considerations, but they are crucial for confirming siRNA efficacy in a living organism. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">10. Cytotoxicity Assay \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: To ensure that the observed gene silencing is not due to cytotoxic effects, viability assays (e.g., MTT, Trypan Blue exclusion) can be used to confirm that the siRNA treatment does not cause significant cell death. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Always include proper controls to differentiate between silencing effects and toxic effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Using a combination of these methods provides a comprehensive understanding of \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002Fadmin\u002FGenCefe%20Biotech%20provides%20high-quality%20siRNA,%20miRNA,%20sgRNA,%20and%20custom%20RNA%20synthesis%20services.%20We%20can%20design%20and%20synthesize%20RNA%20Oligos%20of%20different%20lengths,%20different%20forms,%20and%20with%20various%20modification\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\"> silencing efficacy and ensures that both on-target and off-target effects are carefully evaluated. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-01-07 00:00:00","RNA Synthesis & Modifications—How to assess the silencing effect of siRNA","Assessing the silencing effect of siRNA is crucial to confirm its effectiveness in downregulating target gene expression. Several methods can be used, such as qPCR, Western Blot, ELISA, RNA-seq etc.","RNA Oligo, siRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:34:42",11,"77,72,70,67,65","13,22",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":84,"categoryName":42,"title":85,"imgUrl":86,"content":87,"excerpt":46,"publishDate":88,"seoTitle":89,"seoDesc":90,"seoKeywords":91,"createDate":92,"sort":93,"relatedPostIds":94,"firstServiceProductId":54,"secondServiceProductIds":82,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},66,"What are the main applications of siRNA?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F13_20260630154005A115.png","\u003Cp>\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F13_20260630154013A116.png\" title=\"siRNA\" alt=\"siRNA\" width=\"100%\"\u002F>\u003C\u002Fp>\u003Cp>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA (small interfering RNA)\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\"> \u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\">is a powerful tool for gene silencing, and it has a wide range of applications in both research and therapeutic contexts. Here are the key applications: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1. Gene Function Studies \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To study the function of specific genes by reducing their expression in cells or animals. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Knockdown of target genes to investigate their role in cellular processes such as cell cycle, apoptosis, or metabolism. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Creation of gene knockdowns for understanding disease mechanisms or identifying potential therapeutic targets. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2. Functional Genomics \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To screen and identify genes involved in specific cellular pathways or disease processes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      High-throughput RNAi screening: Systematic knockdown of genes to identify those involved in processes like drug resistance, cancer progression, or immune response. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3. Target Validation in Drug Development \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To validate potential drug targets by silencing specific genes and evaluating the resulting phenotypic changes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Use in early-stage drug discovery to identify and validate targets for new therapeutics, particularly in areas such as cancer, infectious diseases, and neurodegenerative diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4. Cancer Therapy \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To selectively silence genes involved in tumor growth, metastasis, or drug resistance. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Targeting oncogenes or genes that promote cancer cell survival or metastasis, thereby inhibiting tumor growth. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Sensitizing cancer cells to chemotherapy or targeted therapies by silencing drug resistance genes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5. Viral Infections \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To reduce viral replication by silencing viral genes or host cell factors required for virus entry, replication, or assembly. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Developing antiviral therapies by targeting viral RNA, such as for HIV, influenza, hepatitis B, and other viral infections. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">6. Neurological Disorders \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To treat diseases with genetic mutations, like Huntington's disease, by silencing the expression of toxic proteins. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●     Targeting RNA transcripts that encode disease-causing proteins (e.g., silencing mutant huntingtin in Huntington’s disease) or modulating genes related to neurodegeneration. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">7. Gene Silencing in Model Organisms \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To create functional knockdowns in organisms such as mice, rats, or zebrafish for research purposes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: osiRNA is used to knock down genes in in vivo models to study gene function and disease progression, helping to model human diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">8. Disease Treatment (Therapeutics) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To develop siRNA-based therapeutics aimed at silencing disease-causing genes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Gene therapy: siRNA-based drugs are being developed to treat genetic disorders caused by overexpression of disease-causing genes (e.g., spinal muscular atrophy, acute liver diseases). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Ongoing clinical trials are exploring the use of siRNA for conditions like cancer, neurological disorders, and inherited genetic diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">9. Precision Medicine \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To develop personalized therapies by silencing specific genes involved in individual patients' diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Using siRNA to target genes based on the genetic profile of patients, offering more tailored and effective treatment options. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">10. Immune System Modulation \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To manipulate immune responses by silencing immune-related genes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●     Modulating immune checkpoints, cytokine production, or T-cell activation for autoimmune diseases or immunotherapy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●     Enhancing the immune response against infections or cancer by silencing suppressive pathways. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">11. Epigenetic Regulation \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Purpose: To investigate the role of epigenetic regulators in gene expression by silencing genes involved in chromatin modification or DNA methylation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●     Targeting epigenetic modifiers such as histone deacetylases (HDACs) or DNA methyltransferases (DNMTs) to study their effect on gene expression and cellular behavior. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">In conclusion, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> has a broad range of applications across basic research, drug development, and therapeutic interventions, particularly in gene silencing, cancer treatment, viral infections, and genetic disorders. It is also being explored for its potential in precision medicine and immune system modulation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-01-14 00:00:00","RNA Synthesis & Modifications—Applications of siRNA","siRNA has a broad range of applications across basic research, drug development, and therapeutic interventions, particularly in gene silencing, cancer treatment, viral infections, and genetic disorders. It is also being explored for its potential in precision medicine and immune system modulation.","RNA Oligo, siRNA, miRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:36:50",13,"77,72,70,69,65",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":96,"categoryName":42,"title":97,"imgUrl":98,"content":99,"excerpt":46,"publishDate":100,"seoTitle":101,"seoDesc":102,"seoKeywords":103,"createDate":104,"sort":25,"relatedPostIds":105,"firstServiceProductId":54,"secondServiceProductIds":106,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},68,"What are the functions of miRNA inhibitors and mimics in microRNA research?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F15_20260630154315A119.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F15_20260630154322A120.png\" title=\"miRNA inhibitors and mimics\" alt=\"miRNA inhibitors and mimics\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">In microRNA (miRNA) research, inhibitors and mimics are essential tools used to study the biological roles of specific miRNAs by either suppressing or mimicking their functions. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Functions of miRNA Inhibitors \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Function: Suppress the activity of endogenous miRNAs, blocking their regulatory effects on target genes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Mechanism: Antisense oligonucleotides complementary to the mature miRNA bind to the miRNA, preventing its incorporation into the RNA-induced silencing complex (RISC) or its interaction with target mRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Experimental Purpose: Used to study the consequences of miRNA suppression, particularly in conditions where the miRNA is overexpressed, to assess its role in gene regulation and biological processes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: Suitable for investigating miRNA-related mechanisms in diseases, identifying miRNA targets, and validating their biological effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Functions of miRNA Mimics \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Function: Enhance or replicate the function of specific miRNAs to promote their regulatory effects on target genes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Mechanism: Structurally mimic mature miRNAs using double-stranded RNA molecules. Once introduced into cells, mimics are processed by cellular machinery and loaded into RISC to act like endogenous miRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Experimental Purpose: Analyze the impact of miRNA overexpression, validate target gene regulation, and explore the role of specific miRNAs in biological or pathological contexts. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Application: Useful in studying under-expressed miRNAs, exploring therapeutic applications, and confirming miRNA-mRNA interactions. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Key Differences and Application \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">miRNA inhibitors are used to suppress endogenous miRNA activity, making them suitable for studying miRNA inhibition effects. miRNA mimics, on the other hand, are used to enhance or mimic miRNA functions, making them ideal for studying the effects of miRNA overexpression. Combining these tools provides a comprehensive approach to exploring miRNA functions and their roles in specific biological or disease-related processes.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-01-23 00:00:00","RNA Synthesis & Modifications—Functions of miRNA inhibitors and mimics in microRNA research","In microRNA (miRNA) research, inhibitors and mimics are essential tools used to study the biological roles of specific miRNAs by either suppressing or mimicking their functions."," RNA Oligo, miRNA, microRNA, miRNA inhibitors, miRNA mimics, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:38:35","74,72,70,67,65","13,56",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":108,"categoryName":42,"title":109,"imgUrl":110,"content":111,"excerpt":46,"publishDate":112,"seoTitle":113,"seoDesc":114,"seoKeywords":115,"createDate":116,"sort":14,"relatedPostIds":117,"firstServiceProductId":54,"secondServiceProductIds":106,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},72,"What are the differences between miRNA and siRNA?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F19_20260630154853A127.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F19_20260630154859A128.png\" title=\"miRNA and siRNA\" alt=\"miRNA and siRNA\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">MicroRNA (miRNA) and small interfering RNA (siRNA) are both short, non-coding RNA molecules involved in post-transcriptional gene regulation. Despite their similarities, they differ in origin, mechanism, and application.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Ctable cellspacing=\"0\">\u003Ctbody style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctr class=\"firstRow\" style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); text-align: center; border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cbr\u002F>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">miRNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">siRNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Origin\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Endogenously encoded; processed from primary miRNA (pri-miRNA) to mature miRNA.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Often exogenous (synthetic or viral); processed from long double-stranded RNA (dsRNA).\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Structure\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Single-stranded with imperfectly paired hairpin structures.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Double-stranded RNA with perfect complementarity.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Mechanism of Action\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Binds to partially complementary sequences in the 3' UTR of mRNA, leading to translational repression or degradation.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Binds to perfectly complementary sequences, inducing target mRNA cleavage and degradation.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Target Specificity\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Broad target range; regulates multiple genes due to partial complementarity.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Highly specific; targets a single mRNA due to perfect base pairing.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Biological Function\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Regulates endogenous gene expression; involved in development, cell differentiation, and stress responses.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Acts as a defense mechanism against viruses and transposable elements.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Applications\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Biomarkers for disease diagnostics and prognostics; potential for modulating multiple pathways in therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Research tools for gene silencing; therapeutics for precise gene targeting (e.g., ONPATTRO).\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">While both miRNA and siRNA are crucial players in RNA interference, they differ significantly in their origin, targeting mechanisms, and functional roles. miRNAs are endogenous regulators with broader, less specific effects, whereas siRNAs are more specific tools for precise gene silencing, making them complementary in research and therapeutic applications.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-02-27 00:00:00","RNA Synthesis & Modifications—Differences between miRNA and siRNA","miRNAs are endogenous regulators with broader, less specific effects, whereas siRNAs are more specific tools for precise gene silencing, making them complementary in research and therapeutic applications."," RNA Oligo, miRNA, microRNA, siRNA, RNAi, RNA interference, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:49:36","61,60,59,58",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":54,"title":119,"excerpt":120,"content":121,"seoTitle":122,"seoDesc":123,"seoKeywords":124,"sort":125,"createDate":126,"secondColor":127,"showOrderPic":5,"homeState":54,"homePic":128,"homeTitle":129,"homeDesc":130,"homeSort":125,"orderDesc":131,"orderUrl":132,"email":133,"phone":134,"onlineFormUrl":132,"serviceFeatureList":8,"productServiceSubList":8},"RNAi Products & RNA Synthesis","GenCefe Biotech provides high-quality siRNA , miRNA , sgRNA , and custom RNA synthesis and modification. We can design and synthesize RNA of different lengths, different forms, and with various modifications.","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fgencefebio.com\u002FproductsAndservices\u002F1-RNAi_Products_RNA_Synthesis.html\" style=\"font-family: Montserrat; color: rgb(0, 112, 192);\">\u003Cstrong>RNA synthesis\u003C\u002Fstrong>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services, including siRNA, miRNA, sgRNA, and custom RNA oligonucleotide synthesis. We support both customer-designed sequences and custom RNA projects with flexible options for sequence length, modifications, and synthesis specifications. Production scales range from nmol and μmol quantities to larger-scale manufacturing, supporting diverse research and diagnostic development needs. Supported by ISO 9001 and ISO 13485 certified quality management systems, GenCefe delivers reliable RNA products, comprehensive QC documentation, and consistent project support.\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255); line-height: 1.75em;\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px; color: rgb(54, 96, 146);\">RNA Synthesis Service Specifications:\u003C\u002Fspan>\u003Cspan style=\"color: rgb(79, 129, 189);\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px;\">\u003C\u002Fspan>\u003Cspan style=\"font-size: 16px; font-family: Montserrat; font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box;\">\u003C\u002Fspan>\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The following table summarizes our RNA synthesis service options, specifications, and ordering details:\u003C\u002Fspan>\u003C\u002Fp>\u003Ctable>\u003Ctbody style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctr class=\"firstRow\" style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Product Name\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Length\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Amount\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Purification Method\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Turnaround Time (days)*\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Order\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">RNA oligo\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">HPLC\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(0, 0, 0); border-right-color: rgb(0, 0, 0); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Please fill out the \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo order form\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">  and send it via email to \u003C\u002Fspan>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo@gencefebio.com\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Modified\u002FLabeled RNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol, to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Large-scale RNA Synthesis \u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">OD, nmol,\u003Cbr\u002F>milligram, gram\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Get a Quote\u003C\u002Fspan>\u003C\u002Fa>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>\u003Cem style=\"color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px;\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">* Turnaround time refers to the estimated time required for order processing, production, and shipment. 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