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use.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":227,"parentId":207,"title":228,"subTitle":90,"excerpt":229,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},55,"Yeast Expression","Yeast-based expression systems provide a cost-effective option for recombinant protein production, supported by sequence and expression optimization strategies.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":231,"title":232,"excerpt":20,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"sort":20,"createDate":20,"secondColor":20,"showOrderPic":20,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"serviceFeatureList":20,"productServiceSubList":233},7,"Peptide Synthesis & 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libraries.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":48,"parentId":231,"title":238,"subTitle":90,"excerpt":239,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},"Modified\u002FFluorescent Labeled Peptides","GenCefe provides over 300 different peptide modification groups, including: N-\u002FC-terminal modifications, fluorescent labeling, cyclic peptides, biotin labeling, 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maturation.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":276,"parentId":260,"title":277,"subTitle":90,"excerpt":278,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},32,"Controlled (Trimer) Libraries","Controlled (Trimer) libraries use predefined trinucleotide building blocks to precisely control amino acid diversity while reducing codon redundancy for efficient library design.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":280,"parentId":260,"title":281,"subTitle":90,"excerpt":282,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},33,"CRISPR sgRNA Libraries ","CRISPR sgRNA libraries enable high-throughput functional screening for target discovery, functional genomics, and phenotype-based studies.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":284,"title":285,"excerpt":20,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"sort":20,"createDate":20,"secondColor":20,"showOrderPic":20,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"serviceFeatureList":20,"productServiceSubList":286},8,"Reagents & Kits",[],{"msg":4,"code":5,"data":288},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":289,"categoryName":290,"title":291,"imgUrl":292,"content":293,"excerpt":90,"publishDate":294,"seoTitle":295,"seoDesc":296,"seoKeywords":297,"createDate":298,"sort":211,"relatedPostIds":299,"firstServiceProductId":61,"secondServiceProductIds":300,"relatedPost":301,"productService":356,"allSecondProductService":370,"twoSecondProductService":378},76,"RNA & Nucleic Acid Drug","What is the current progress in sgRNA drug research?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F22_20260630155259A133.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F22_20260630155306A134.png\" title=\"sgRNA drug research\" alt=\"sgRNA drug research\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Single-guide RNA (sgRNA) has emerged as a pivotal tool in CRISPR-based genome editing, facilitating precise and programmable modifications of DNA or RNA. As part of CRISPR-Cas systems, sgRNA plays a central role in directing Cas proteins to specific genomic loci. Its therapeutic applications have progressed significantly, with notable advancements in treating genetic diseases, cancers, and infectious diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1. Therapeutic Applications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Genetic Disorders: sgRNA-guided CRISPR systems are used to correct pathogenic mutations in diseases such as sickle cell anemia, β-thalassemia, and cystic fibrosis. Ongoing clinical trials aim to demonstrate the safety and efficacy of these approaches. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Oncology: sgRNA is being explored to target oncogenes, enhance immune checkpoint inhibition, or engineer CAR-T cells for improved anti-tumor activity. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Infectious Diseases: CRISPR-sgRNA systems are applied to combat viral infections, such as HIV and hepatitis B, by targeting viral genomes for degradation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2. Advancements in sgRNA Design \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Enhanced Specificity: Improved sgRNA algorithms and chemical modifications have reduced off-target effects, ensuring higher precision in genome editing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Multiplexing: Advanced sgRNA strategies allow simultaneous targeting of multiple genes, broadening therapeutic potential. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Base Editing and Prime Editing: sgRNAs now facilitate precise base conversions and targeted DNA insertions without introducing double-strand breaks, minimizing unintended consequences. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3. Delivery Innovations \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Lipid Nanoparticles (LNPs): Widely used for delivering sgRNA-Cas complexes in vivo, particularly for liver-targeted therapies. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Adeno-associated Viruses (AAVs): Commonly employed for delivering sgRNA and Cas components to specific tissues, with promising results in preclinical studies. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Ribonucleoprotein (RNP) Complexes: Direct delivery of sgRNA pre-complexed with Cas proteins has shown improved editing efficiency and reduced immunogenicity. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4. Clinical Progress \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Ex Vivo Editing: Several clinical trials use sgRNA-directed CRISPR to edit patient-derived cells, such as hematopoietic stem cells, before reintroducing them to the patient. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      In Vivo Editing: Companies like Intellia Therapeutics are conducting trials using sgRNA-based CRISPR systems for in vivo genome editing, targeting conditions like transthyretin amyloidosis (ATTR). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Ongoing Trials: Trials for conditions including Leber congenital amaurosis (LCA), sickle cell anemia, and β-thalassemia are demonstrating encouraging preliminary results.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">sgRNA-based therapeutics have revolutionized genome editing, offering unprecedented precision and versatility. Advances in sgRNA design, delivery, and clinical translation are driving progress, with several therapies nearing commercialization. Continued innovation in this field holds the promise of addressing previously untreatable genetic and complex diseases.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-03-11 00:00:00","RNA Synthesis & Modifications—Progress in sgRNA drug research","Advances in sgRNA design, delivery, and clinical translation are driving progress, with several therapies nearing commercialization. Continued innovation in this field holds the promise of addressing previously untreatable genetic and complex diseases.","RNA Oligo, sgRNA, guide RNA, gene editing, CRISPR, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:52:26","73,69,65,63,60","13,58",[302,313,324,334,346],{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":43,"categoryName":290,"title":303,"imgUrl":304,"content":305,"excerpt":90,"publishDate":306,"seoTitle":307,"seoDesc":308,"seoKeywords":309,"createDate":310,"sort":231,"relatedPostIds":311,"firstServiceProductId":61,"secondServiceProductIds":312,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},"What are the common types of modifications for small nucleic acids and their main functions?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F07_20260630144718A101.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F07_20260630144724A102.png\" title=\" RNA modifications, custom RNA synthesis\" alt=\" RNA modifications, custom RNA synthesis\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Various modifications are applied to small nucleic acids to enhance their stability, reduce immunogenicity, and improve targeting. Below are the most commonly used modifications and their primary functions: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Phosphorothioate (PS) Modification: Substitution of one of the non-bridging oxygen atoms in the phosphodiester backbone with sulfur. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Increases stability by protecting against nuclease degradation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    2'-O-Methyl (2'-OMe) Modification: Addition of a methyl group at the 2' position of the ribose sugar. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Enhances resistance to nuclease activity and reduces immune activation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Locked Nucleic Acid (LNA): Modification of the ribose sugar to "lock" the sugar in a particular conformation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Improves hybridization affinity and stability, especially for ASOs and miRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Fluorescent Labels: Attachment of fluorescent molecules to the oligonucleotide. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Used for tracking, imaging, and studying the distribution of nucleic acids. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Cholesterol Conjugation: Adding a cholesterol group to the oligonucleotide. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Enhances cellular uptake and promotes delivery across cell membranes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Polyethylene Glycol (PEG) Conjugation: Attachment of PEG chains to the nucleic acid. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Increases solubility, reduces immunogenicity, and prolongs circulation time in vivo. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">These modifications are strategically used to optimize the pharmacokinetics, stability, and therapeutic efficacy of small nucleic acids.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-24 00:00:00","RNA Synthesis & Modifications—RNA modifications and their functions","Various modifications are applied to small nucleic acids to enhance their stability, reduce immunogenicity, and improve targeting, such as PS, 2'-OMe, LNA, etc.","RNA Oligo, siRNA, miRNA, Antisense Oligo, RNA modifications, custom RNA synthesis","2025-04-28 17:06:54","78,75,73,70,68","13,60",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":138,"categoryName":290,"title":314,"imgUrl":315,"content":316,"excerpt":90,"publishDate":317,"seoTitle":318,"seoDesc":319,"seoKeywords":320,"createDate":321,"sort":197,"relatedPostIds":322,"firstServiceProductId":61,"secondServiceProductIds":323,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},"What are the key considerations in siRNA design?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F10_20260630145140A109.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F10_20260630145147A110.png\" title=\"key considerations\" alt=\"key considerations\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Designing effective \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> involves several important factors to ensure high silencing efficiency, specificity, and minimal off-target effects. Below are the key considerations when designing siRNA: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1. Target Sequence Selection \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Select an Efficient Target Region: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Choose a target sequence that is highly conserved among species and is ideally located in the 3' untranslated region (UTR) or coding region to maximize gene silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Avoid Off-Target Sequences: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Ensure that the siRNA sequence does not significantly match other genes in the genome to reduce off-target effects. Tools like BLAST can be used to assess off-target potential. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Preferably Avoid Sequence with Secondary Structures: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Select target sequences that do not form strong secondary structures (such as hairpins), as these can hinder the binding of the siRNA to the mRNA. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2. siRNA Duplex Design \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Guide and Passenger Strand Balance: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The guide strand is the one that binds to the target mRNA, while the passenger strand is degraded. Ensure that the guide strand is selected from the most potent position, usually the middle of the target sequence. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    The guide strand should have a 5' phosphate, and the passenger strand should have a 3' overhang for efficient loading into the RNA-induced silencing complex (RISC). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Strand Stability: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Ensure a proper balance in the melting temperature (Tm) between the two strands. The 5' end of the guide strand should ideally be more stable than the passenger strand to promote unwinding of the duplex and incorporation of the guide strand into RISC. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3. siRNA Length \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Typically 19-23 Nucleotides: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">siRNA is typically designed to be 19-23 base pairs long. This length is optimal for efficient cleavage by the RNA-induced silencing complex (RISC) and minimizes the risk of immune activation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4. Chemical Modifications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Phosphorothioate Backbone Modification:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Introduce phosphorothioate modifications at the 3' and\u002For 5' ends of the siRNA to increase stability against nucleases in serum and cellular environments. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    2'-O-Methyl and 2'-Fluoro Modifications: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Use these modifications to protect the siRNA from degradation and reduce activation of innate immune responses by Toll-like receptors (TLRs). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Cholesterol Conjugation (for in vivo): \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Conjugate cholesterol to the siRNA (typically at the 3' end) to enhance cellular uptake, particularly for liver-targeted siRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5. GC Content \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    GC Content of 30-50%: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Ideally, the GC content of the siRNA should be balanced to ensure optimal stability and efficient hybridization with the target mRNA. Avoid sequences that are too rich in GC, as they may form secondary structures. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">6. Avoid Sequence Homology with Other Genes \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Minimize Homology with Off-Target Genes: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Ensure that the siRNA sequence does not have significant homology with unintended genes to minimize off-target silencing effects. This can be assessed through bioinformatics tools to check for off-target sequences. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">7. Avoid Immunostimulatory Sequences \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Avoid PAMP Motifs: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Avoid sequences that might trigger immune responses (e.g., patterns recognized by Toll-like receptors or other immune sensors). This can be especially critical for in vivo applications where systemic immune activation could limit efficacy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">8. 5’ and 3’ End Modifications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    3' Overhang: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">For efficient incorporation into the RISC complex, siRNAs typically have a 3' overhang of 2–3 nucleotides. This facilitates the unwinding of the duplex and guide strand loading. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    5' Phosphate Group: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The guide strand should have a 5' phosphate, which is essential for RISC binding and mRNA cleavage. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">9. Secondary Structure Considerations \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Minimize Hairpin or G-Quadruplex Formation: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Avoid sequences that form strong secondary structures, such as hairpins, as these can inhibit efficient siRNA-mRNA hybridization and reduce silencing efficacy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">10. Target Gene Validation \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Validate Target mRNA Structure: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Before siRNA design, ensure that the target mRNA is accessible and that there are no structural elements (like G-quadruplexes) that would prevent siRNA binding. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Efficient \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> design involves a careful balance between target specificity, stability, and minimizing immune responses or off-target effects. Key considerations include selecting optimal target sequences, modifying the siRNA backbone for stability, ensuring proper strand orientation and length, and using chemical modifications to improve pharmacokinetics, particularly for in vivo applications. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-01-02 00:00:00","RNA Synthesis & Modifications—Key considerations in siRNA design","Key considerations of siRNA design include selecting optimal target sequences, modifying the siRNA backbone for stability, ensuring proper strand orientation and length, and using chemical modifications to improve pharmacokinetics, particularly for in vivo applications.","RNA Oligo, siRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis, siRNA design","2025-04-30 16:33:39","77,69,62,59,57","13,22",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":147,"categoryName":290,"title":325,"imgUrl":326,"content":327,"excerpt":90,"publishDate":328,"seoTitle":329,"seoDesc":330,"seoKeywords":331,"createDate":332,"sort":64,"relatedPostIds":333,"firstServiceProductId":61,"secondServiceProductIds":300,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},"What is the difference between siRNA and sgRNA?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F12_20260630153901A113.png","\u003Cp>\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F12_20260630153907A114.png\" title=\"siRNA and sgRNA\" alt=\"siRNA and sgRNA\" width=\"100%\"\u002F>\u003C\u002Fp>\u003Cp>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA (small interfering RNA)\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\"> \u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\">and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA (single guide RNA)\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\"> \u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\">are both short RNA molecules involved in RNA-mediated gene silencing, but they function in different RNA interference pathways and have distinct roles. Here are the key differences:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Ctable cellspacing=\"0\">\u003Ctbody style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctr class=\"firstRow\" style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Feature\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">siRNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">sgRNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Function\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">RNA interference (gene silencing)\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">CRISPR-Cas9 genome editing\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Target\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">mRNA (post-transcriptionally)\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">DNA (for genetic modification)\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Structure\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">20-25 base pairs, duplex\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">100-120 nucleotides, single guide\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Origin\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Derived from long dsRNA or synthetic\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Engineered RNA, part of CRISPR-Cas9 system\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Purpose\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Gene silencing or knockdown\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Gene editing (DNA modification)\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Applications\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Functional genomics, therapeutics\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Genome editing, gene knockout\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Mechanism\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">mRNA degradation via RISC\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">DNA cleavage via Cas9 endonuclease\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">In summary, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> is used for RNA-based gene silencing by targeting mRNA, while \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> is used in CRISPR-Cas9 systems for precise genome editing at the DNA level. Both are powerful tools but serve different purposes in molecular biology and gene therapy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-01-09 00:00:00","RNA Synthesis & Modifications—What is the difference between siRNA and sgRNA","siRNA (small interfering RNA) and sgRNA (single guide RNA) are both short RNA molecules involved in RNA-mediated gene silencing, but they function in different RNA interference pathways and have distinct roles.","RNA Oligo, siRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:35:23","77,70,69,68,67",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":335,"categoryName":290,"title":336,"imgUrl":337,"content":338,"excerpt":90,"publishDate":339,"seoTitle":340,"seoDesc":341,"seoKeywords":342,"createDate":343,"sort":41,"relatedPostIds":344,"firstServiceProductId":61,"secondServiceProductIds":345,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},69,"What is the current progress in miRNA therapeutics research?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F16_20260630154431A121.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F16_20260630154437A122.png\" title=\"miRNA therapeutics research\" alt=\"miRNA therapeutics research\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">MicroRNA (miRNA) therapeutics research has achieved significant milestones, highlighting its potential for treating complex diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.Therapeutic Applications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      miRNAs have been identified as key regulators in various diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and metabolic syndromes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Therapeutic strategies involve miRNA mimics to replenish downregulated miRNAs and miRNA inhibitors (antagomiRs) to block the activity of overexpressed miRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.Clinical Trials \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Multiple miRNA-based drugs have entered clinical trials. Examples include: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      MRG-110, targeting miRNA-92a to promote angiogenesis in ischemic diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      RG-012, designed to inhibit miRNA-21 for treating Alport syndrome. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3.Innovative Delivery Systems \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Advanced delivery methods, such as lipid nanoparticles (LNPs), exosome-based carriers, and viral vectors, have enhanced the stability and cellular uptake of miRNA therapeutics. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Tissue-specific targeting has been a primary goal to reduce systemic side effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4.Chemical Modifications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Chemical enhancements, such as locked nucleic acids (LNAs), 2'-O-methylation, and phosphorothioates, have improved the stability, efficacy, and safety of miRNA drugs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5.Biomarker Development \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      miRNAs are being developed as diagnostic and prognostic biomarkers for diseases such as cancer and cardiovascular conditions, facilitating personalized medicine approaches. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Recent advancements in miRNA therapeutics demonstrate their potential for treating previously untreatable diseases. Key innovations in delivery technologies, chemical modifications, and biomarker applications are paving the way for miRNA-based therapies to transition from experimental to clinical use.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-02-13 00:00:00","RNA Synthesis & Modifications—Progress in miRNA therapeutics research","Recent advancements in miRNA therapeutics demonstrate their potential for treating previously untreatable diseases. Key innovations in delivery technologies, chemical modifications, and biomarker applications are paving the way for miRNA-based therapies to transition from experimental to clinical use."," RNA Oligo, miRNA, microRNA, miRNA inhibitors, miRNA mimics, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:42:25","77,75,71,68,64","13,56",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":204,"categoryName":290,"title":347,"imgUrl":348,"content":349,"excerpt":90,"publishDate":350,"seoTitle":351,"seoDesc":352,"seoKeywords":353,"createDate":354,"sort":29,"relatedPostIds":355,"firstServiceProductId":61,"secondServiceProductIds":312,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},"What is the current progress in antisense oligonucleotide (ASO) drug development? ","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F20_20260630155023A129.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F20_20260630155029A130.png\" title=\"antisense oligonucleotide (ASO) drug development\" alt=\"antisense oligonucleotide (ASO) drug development\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Antisense oligonucleotide (ASO) drugs have advanced significantly, establishing themselves as a versatile and effective platform for treating genetic and other complex diseases. Key progress includes the following: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1. Approved ASO Therapies \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Several ASO drugs have been approved for clinical use, addressing a wide range of conditions: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Nusinersen (Spinraza): The first FDA-approved ASO for spinal muscular atrophy (SMA), developed by Ionis Pharmaceuticals and Biogen. It targets the SMN2 gene to enhance functional SMN protein production. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Mipomersen (Kynamro): Used to treat familial hypercholesterolemia by reducing apolipoprotein B (ApoB) production. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Eteplirsen (Exondys 51): Targets exon skipping in the dystrophin gene for Duchenne muscular dystrophy (DMD). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2. Expanding Disease Applications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Neurological Diseases: ASOs have shown promise in treating Huntington’s disease (e.g., Tominersen) and amyotrophic lateral sclerosis (ALS). These drugs are designed to reduce harmful protein accumulation or correct splicing defects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Oncology: ASOs are being investigated to silence oncogenes or re-sensitize tumors to chemotherapy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Metabolic Disorders: Targeting liver-specific pathways, ASOs like inclisiran reduce low-density lipoprotein (LDL) cholesterol. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3. Innovations in Chemistry \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Chemical modifications have improved ASO stability, delivery, and efficacy: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Phosphorothioate Backbones: Enhance stability and resistance to nucleases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      2'-O-Methyl (2'-OMe) and 2'-Methoxyethyl (2'-MOE): Increase binding affinity and reduce toxicity. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Gapmers: ASOs designed to activate RNase H-mediated cleavage, improving potency. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4. Delivery Advancements \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Targeted Delivery: Liver-specific delivery through conjugates like N-acetylgalactosamine (GalNAc) has reduced off-target effects and improved safety profiles. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Intrathecal Administration: Direct delivery to the central nervous system (CNS) for neurological diseases, bypassing the blood-brain barrier. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5. Ongoing Clinical Trials \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Dozens of ASO drugs are in clinical development, targeting diseases such as Alzheimer’s, cancer, and rare genetic conditions. Emerging therapies include RNA-targeting ASOs for exon skipping, splicing correction, and gene silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">ASO drug development has achieved remarkable progress, with approved therapies addressing rare genetic diseases and expanding into more prevalent conditions like cancer and neurological disorders. Advances in chemistry, delivery systems, and disease-specific targeting are driving the growth of ASOs as a transformative therapeutic platform.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-02-27 00:00:00","RNA Synthesis & Modifications—Progress in antisense oligonucleotide (ASO) drug development"," ASO drug development has achieved remarkable progress, with approved therapies addressing rare genetic diseases and expanding into more prevalent conditions like cancer and neurological disorders.","RNA Oligo, ASO, antisense oligo, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:50:17","67,66,65,64,63",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":61,"title":93,"excerpt":357,"content":358,"seoTitle":359,"seoDesc":360,"seoKeywords":361,"sort":362,"createDate":363,"secondColor":364,"showOrderPic":5,"homeState":61,"homePic":365,"homeTitle":366,"homeDesc":367,"homeSort":362,"orderDesc":368,"orderUrl":369,"email":14,"phone":15,"onlineFormUrl":369,"serviceFeatureList":20,"productServiceSubList":20},"GenCefe Biotech provides high-quality siRNA , miRNA , sgRNA , and custom RNA synthesis and modification. We can design and synthesize RNA of different lengths, different forms, and with various modifications.","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fgencefebio.com\u002FproductsAndservices\u002F1-RNAi_Products_RNA_Synthesis.html\" style=\"font-family: Montserrat; color: rgb(0, 112, 192);\">\u003Cstrong>RNA synthesis\u003C\u002Fstrong>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services, including siRNA, miRNA, sgRNA, and custom RNA oligonucleotide synthesis. We support both customer-designed sequences and custom RNA projects with flexible options for sequence length, modifications, and synthesis specifications. Production scales range from nmol and μmol quantities to larger-scale manufacturing, supporting diverse research and diagnostic development needs. Supported by ISO 9001 and ISO 13485 certified quality management systems, GenCefe delivers reliable RNA products, comprehensive QC documentation, and consistent project support.\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255); line-height: 1.75em;\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px; color: rgb(54, 96, 146);\">RNA Synthesis Service Specifications:\u003C\u002Fspan>\u003Cspan style=\"color: rgb(79, 129, 189);\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px;\">\u003C\u002Fspan>\u003Cspan style=\"font-size: 16px; font-family: Montserrat; font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box;\">\u003C\u002Fspan>\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The following table summarizes our RNA synthesis service options, specifications, and ordering details:\u003C\u002Fspan>\u003C\u002Fp>\u003Ctable>\u003Ctbody style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctr class=\"firstRow\" style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Product Name\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Length\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Amount\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Purification Method\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Turnaround Time (days)*\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Order\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">RNA oligo\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">HPLC\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(0, 0, 0); border-right-color: rgb(0, 0, 0); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Please fill out the \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo order form\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">  and send it via email to \u003C\u002Fspan>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo@gencefebio.com\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Modified\u002FLabeled RNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol, to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Large-scale RNA Synthesis \u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">OD, nmol,\u003Cbr\u002F>milligram, gram\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Get a Quote\u003C\u002Fspan>\u003C\u002Fa>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>\u003Cem style=\"color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px;\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">* Turnaround time refers to the estimated time required for order processing, production, and shipment. Actual delivery times may vary depending on the destination and courier transit time.\u003C\u002Fspan>\u003C\u002Fem>\u003C\u002Fp>","RNA Synthesis | Fast Delivery & 50K+ siRNA Sets-GenCefe","GenCefe provides siRNA, miRNA, sgRNA, pegRNA, and custom RNA synthesis and modification services for RNAi, gene editing, and gene regulation.","RNA Synthesis, custom RNA oligo, RNA oligo synthesis, siRNA, miRNA, sgRNA, Antisense oligo",88,"2024-10-24 14:13:06","#48bfea","https:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2025\u002F04\u002F20\u002FRNA合成_蓝_20250420143026A002.png","RNA Synthesis","Custom synthesis and modification. 50,000+ pre-designed siRNA sets","Advance your RNA research with flexible RNA synthesis services, expert support, and dependable project execution.","https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM",[371,372,373,374,375,376,377],{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":96,"parentId":61,"title":97,"subTitle":98,"excerpt":99,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":101,"parentId":61,"title":102,"subTitle":103,"excerpt":104,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":61,"newState":5,"type":105,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":107,"parentId":61,"title":108,"subTitle":109,"excerpt":110,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":112,"parentId":61,"title":113,"subTitle":114,"excerpt":115,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":117,"parentId":61,"title":118,"subTitle":119,"excerpt":120,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":61,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":43,"parentId":61,"title":122,"subTitle":90,"excerpt":123,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":125,"parentId":61,"title":126,"subTitle":90,"excerpt":127,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},[379,380],{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":96,"parentId":61,"title":97,"subTitle":98,"excerpt":99,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":112,"parentId":61,"title":113,"subTitle":114,"excerpt":115,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":62,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20}]