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acids.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":187,"parentId":179,"title":188,"subTitle":59,"excerpt":189,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},38,"Bacterial Expression","GenCefe provides E. coli–based protein expression services with optimization of gene design, vectors, fusion tags, and expression conditions to improve protein yield and solubility.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":191,"parentId":179,"title":192,"subTitle":59,"excerpt":193,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},53,"Mammalian Cell Expression","GenCefe’s mammalian expression systems (CHO and HEK293) produce recombinant proteins and antibodies with proper post-translational modifications for functionally relevant applications.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":195,"parentId":179,"title":196,"subTitle":59,"excerpt":197,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},54,"Insect Cell\u002FBaculovirus Expression","The insect cell\u002Fbaculovirus system enables eukaryotic protein expression with complex folding and post-translational modifications, suitable for research and development 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Modification",[206,210,214,218,222,226,230],{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":207,"parentId":203,"title":208,"subTitle":59,"excerpt":209,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},19,"Custom Peptide Synthesis","GenCefe Biotech uses solid- and liquid-phase peptide synthesis to deliver high-quality custom, modified, labeled, cyclized peptides, glycopeptides, and libraries.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":211,"parentId":203,"title":212,"subTitle":59,"excerpt":213,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},18,"Modified\u002FFluorescent Labeled Peptides","GenCefe provides over 300 different peptide modification groups, including: N-\u002FC-terminal modifications, fluorescent labeling, cyclic peptides, biotin labeling, etc.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":215,"parentId":203,"title":216,"subTitle":59,"excerpt":217,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},17,"Stable Isotope-Labeled Peptides","GenCefe offers custom stable isotope-labeled peptides by incorporating isotope-labeled amino acids like C and N directly during synthesis, labeling the entire peptide chain.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":219,"parentId":203,"title":220,"subTitle":59,"excerpt":221,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},44,"Cyclic Peptide Synthesis","GenCefe Biotech provides clyclic peptide synthesis services, including Stapled Peptides, Cyclization at side chain, Head-to-tail cyclization, etc.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":223,"parentId":203,"title":224,"subTitle":59,"excerpt":225,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},45,"Glycopeptides","GenCefe Biotech provides glycosylation modification services, producing glycopeptides with N-linked and O-linked types to enhance protein stability, activity, and cell signaling.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":227,"parentId":203,"title":228,"subTitle":59,"excerpt":229,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},46,"Peptide Libraries","GenCefe Biotech provides a variety of peptide library synthesis services, including over lapping libraries, random libraries, amino acid scanning libraries, etc.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":231,"parentId":203,"title":232,"subTitle":59,"excerpt":233,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":74,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},47,"Catalog Peptides","GenCefe Biotech offers over 2,000 catalog peptides covering popular research areas, available from stock.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":235,"title":236,"excerpt":20,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"sort":20,"createDate":20,"secondColor":20,"showOrderPic":20,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"serviceFeatureList":20,"productServiceSubList":237},4,"Synthetic DNA 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optimization.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":243,"parentId":235,"title":244,"subTitle":59,"excerpt":245,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},21,"Random Mutagenesis Libraries","Random mutagenesis libraries generate diverse sequence variants through random nucleotide mutations, making them ideal for directed evolution and functional discovery.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":247,"parentId":235,"title":248,"subTitle":59,"excerpt":249,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},31,"Degenerate (Saturation Mutagenesis) Libraries","Degenerate (saturation mutagenesis) libraries introduce NNK or NNN codons at selected positions to generate broad amino acid diversity for protein engineering and affinity maturation.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":251,"parentId":235,"title":252,"subTitle":59,"excerpt":253,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},32,"Controlled (Trimer) Libraries","Controlled (Trimer) libraries use predefined trinucleotide building blocks to precisely control amino acid diversity while reducing codon redundancy for efficient library design.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":255,"parentId":235,"title":256,"subTitle":59,"excerpt":257,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},33,"CRISPR sgRNA Libraries ","CRISPR sgRNA libraries enable high-throughput functional screening for target discovery, functional genomics, and phenotype-based studies.",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":259,"title":260,"excerpt":20,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"sort":20,"createDate":20,"secondColor":20,"showOrderPic":20,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"serviceFeatureList":20,"productServiceSubList":261},8,"Reagents & Kits",[],{"msg":4,"code":5,"data":263},[264,272,276,279,282,284],{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"parentName":20,"parentId":5,"orderNum":20,"ancestors":20,"id":21,"title":265,"excerpt":20,"content":20,"publishDate":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"productServiceId":20,"sort":266,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"applicationsSubList":267,"productService":20},"Oligonucleotide 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platform",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"parentName":20,"parentId":5,"orderNum":20,"ancestors":20,"id":273,"title":274,"excerpt":20,"content":20,"publishDate":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"productServiceId":20,"sort":275,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"applicationsSubList":20,"productService":20},14,"Gene&Genome Editing",80,{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"parentName":20,"parentId":5,"orderNum":20,"ancestors":20,"id":277,"title":278,"excerpt":20,"content":20,"publishDate":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"productServiceId":20,"sort":134,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"applicationsSubList":20,"productService":20},15,"Synthetic Biology",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"parentName":20,"parentId":5,"orderNum":20,"ancestors":20,"id":280,"title":281,"excerpt":20,"content":20,"publishDate":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"productServiceId":20,"sort":91,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"applicationsSubList":20,"productService":20},16,"Antibody Drug Discovery",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"parentName":20,"parentId":5,"orderNum":20,"ancestors":20,"id":215,"title":283,"excerpt":20,"content":20,"publishDate":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"productServiceId":20,"sort":47,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"applicationsSubList":20,"productService":20},"IVD Raw Material",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"parentName":20,"parentId":5,"orderNum":20,"ancestors":20,"id":211,"title":285,"excerpt":20,"content":20,"publishDate":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"productServiceId":20,"sort":286,"homeState":20,"homePic":20,"homeTitle":20,"homeDesc":20,"homeSort":20,"applicationsSubList":20,"productService":20},"Vaccine and Novel Therapy",40,{"msg":4,"code":5,"data":288},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":289,"categoryName":290,"title":291,"imgUrl":292,"content":293,"excerpt":59,"publishDate":294,"seoTitle":295,"seoDesc":296,"seoKeywords":297,"createDate":298,"sort":70,"relatedPostIds":299,"firstServiceProductId":29,"secondServiceProductIds":300,"relatedPost":301,"productService":344,"allSecondProductService":358,"twoSecondProductService":366},75,"RNA & Nucleic Acid Drug","What are the ASO pipelines currently in clinical stages? ","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F21_20260630155158A131.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F21_20260630155203A132.png\" title=\"ASO pipelines\" alt=\"ASO pipelines\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Antisense oligonucleotide (ASO) drugs have shown significant progress in clinical development, targeting a wide range of diseases, from rare genetic disorders to more common conditions. Since the approval of the first ASO drug, Fomivirsen, in 1998, the pipeline has expanded substantially. Here are some key ASO drugs currently in clinical stages: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Approved ASO Drugs \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Nusinersen (Spinraza): Approved in 2016 by the FDA for treating spinal muscular atrophy (SMA). It enhances the production of functional SMN protein. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Eteplirsen: Approved for Duchenne muscular dystrophy (DMD), it promotes exon skipping to restore functional dystrophin protein. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Inotersen: Approved for hereditary transthyretin-mediated amyloidosis (hATTR), it reduces transthyretin protein levels to slow disease progression. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">ASO Drugs in Clinical Trials \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Tominersen: Designed for Huntington’s disease, it reduces mutant huntingtin protein levels. Currently in Phase II clinical trials. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      ON363: Targets FUS-related amyotrophic lateral sclerosis (ALS) by decreasing FUS protein production. It has reached Phase III clinical trials. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      ALG-020572: A novel ASO for chronic hepatitis B (CHB) treatment, currently in Phase I trials. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      IONIS-TTR-LRx: A liver-targeting ASO for hATTR amyloidosis, improving delivery efficiency with GalNAc conjugation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Global and Regional Progress\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">ASO development is advancing globally, with contributions from leading biotechnology companies and institutions. In China, domestic enterprises such as Hengrui Medicine are developing ASO drugs, with 16 oligonucleotide-based candidates approved for clinical studies, marking a significant milestone in local innovation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The ASO clinical pipeline has grown to address diverse diseases, including neurodegenerative disorders, rare genetic diseases, and viral infections. Advances in chemical modifications, delivery systems, and disease-specific targeting continue to drive the evolution of ASO therapeutics. These developments promise to bring more ASO drugs to market, benefiting patients worldwide.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-03-06 00:00:00","RNA Synthesis & Modifications—ASO pipelines currently in clinical stages","The ASO clinical pipeline has grown to address diverse diseases, including neurodegenerative disorders, rare genetic diseases, and viral infections.","RNA Oligo, ASO, antisense oligo, RNAi, RNA interference, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:51:38","71,67,64,60","13,60",[302,312,323,334],{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":91,"categoryName":290,"title":303,"imgUrl":304,"content":305,"excerpt":59,"publishDate":306,"seoTitle":307,"seoDesc":308,"seoKeywords":309,"createDate":310,"sort":203,"relatedPostIds":311,"firstServiceProductId":29,"secondServiceProductIds":300,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},"What are the common types of modifications for small nucleic acids and their main functions?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F07_20260630144718A101.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F07_20260630144724A102.png\" title=\" RNA modifications, custom RNA synthesis\" alt=\" RNA modifications, custom RNA synthesis\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Various modifications are applied to small nucleic acids to enhance their stability, reduce immunogenicity, and improve targeting. Below are the most commonly used modifications and their primary functions: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Phosphorothioate (PS) Modification: Substitution of one of the non-bridging oxygen atoms in the phosphodiester backbone with sulfur. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Increases stability by protecting against nuclease degradation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    2'-O-Methyl (2'-OMe) Modification: Addition of a methyl group at the 2' position of the ribose sugar. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Enhances resistance to nuclease activity and reduces immune activation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Locked Nucleic Acid (LNA): Modification of the ribose sugar to "lock" the sugar in a particular conformation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Improves hybridization affinity and stability, especially for ASOs and miRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Fluorescent Labels: Attachment of fluorescent molecules to the oligonucleotide. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Used for tracking, imaging, and studying the distribution of nucleic acids. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Cholesterol Conjugation: Adding a cholesterol group to the oligonucleotide. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Enhances cellular uptake and promotes delivery across cell membranes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Polyethylene Glycol (PEG) Conjugation: Attachment of PEG chains to the nucleic acid. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Increases solubility, reduces immunogenicity, and prolongs circulation time in vivo. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">These modifications are strategically used to optimize the pharmacokinetics, stability, and therapeutic efficacy of small nucleic acids.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-24 00:00:00","RNA Synthesis & Modifications—RNA modifications and their functions","Various modifications are applied to small nucleic acids to enhance their stability, reduce immunogenicity, and improve targeting, such as PS, 2'-OMe, LNA, etc.","RNA Oligo, siRNA, miRNA, Antisense Oligo, RNA modifications, custom RNA synthesis","2025-04-28 17:06:54","78,75,73,70,68",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":112,"categoryName":290,"title":313,"imgUrl":314,"content":315,"excerpt":59,"publishDate":316,"seoTitle":317,"seoDesc":318,"seoKeywords":319,"createDate":320,"sort":25,"relatedPostIds":321,"firstServiceProductId":29,"secondServiceProductIds":322,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},"How to assess the silencing effect of siRNA?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F11_20260630145425A111.png","\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F11_20260630145430A112.png\" title=\"silencing\" alt=\"silencing\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Assessing the silencing effect of \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002Fadmin\u002FGenCefe%20Biotech%20provides%20high-quality%20siRNA,%20miRNA,%20sgRNA,%20and%20custom%20RNA%20synthesis%20services.%20We%20can%20design%20and%20synthesize%20RNA%20Oligos%20of%20different%20lengths,%20different%20forms,%20and%20with%20various%20modification\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 16px;\">siRNA\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\"> is crucial to confirm its effectiveness in downregulating target gene expression. Several methods can be used to evaluate the silencing efficiency of siRNA. Below are the most common approaches: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">1. mRNA Expression Analysis (Quantitative PCR) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: Measure the mRNA levels of the target gene before and after siRNA treatment using quantitative PCR (qPCR). A decrease in mRNA levels indicates effective silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Ensure that the primers used are specific for the target gene and not other homologous genes to avoid off-target effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">2. Western Blotting \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: Western blotting detects the protein levels of the target gene. If the siRNA is effective, a significant reduction in protein expression should be observed compared to the control. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Antibodies used for detection must be highly specific to the target protein. This method can be more informative than qPCR since it measures the actual protein product. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">3. Reporter Assay (Luciferase or GFP Reporter) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: If the target gene has been fused to a reporter gene (such as luciferase or GFP), the expression of the reporter can be measured. A decrease in reporter signal indicates effective siRNA silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Reporter assays are useful for measuring the impact of siRNA on specific targets, and they are relatively easy to quantify. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4. Flow Cytometry (for Fluorescent Proteins or Surface Markers) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: If the target gene influences cell surface markers or a fluorescent protein (e.g., GFP or mCherry), flow cytometry can be used to quantify changes in expression at the single-cell level. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Flow cytometry is powerful for analyzing heterogeneous cell populations and detecting slight variations in silencing efficacy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5. RNA Sequencing (RNA-Seq) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: RNA-Seq is a high-throughput sequencing technique that can be used to evaluate changes in global gene expression profiles upon siRNA treatment. It can identify not only the target gene but also potential off-target effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: This method provides a comprehensive view but can be more expensive and requires more extensive data analysis. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">6. Quantification of Targeted mRNA by Northern Blotting \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: Northern blotting can be used to detect and quantify specific mRNA species, including any potential cleavage products of the target mRNA. A reduction in the target mRNA band indicates effective silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Although more labor-intensive than qPCR, Northern blotting can provide additional information about the size and structure of the mRNA. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">7. Cell Phenotype Analysis \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: Analyze changes in cell phenotype (e.g., morphology, proliferation, apoptosis) after siRNA treatment, particularly if the target gene plays a role in a specific cellular process. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: This can be used as a functional readout, but it is often more difficult to directly attribute changes to specific target genes without further validation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">8. ELISA (Enzyme-Linked Immunosorbent Assay) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: If the target gene produces a secreted protein (e.g., cytokines, growth factors), ELISA can quantify the protein in the culture medium to assess the effect of siRNA on secretion. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: ELISA is useful for monitoring secreted proteins, but it requires high specificity of the antibody and the availability of commercial kits for the target protein. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">9. In Vivo Validation (Animal Models) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: In animal models, siRNA is delivered systemically or locally, and silencing effects are assessed by measuring mRNA and protein expression, or phenotypic changes (e.g., tumor growth reduction, liver disease markers). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: In vivo experiments are more complex and require ethical considerations, but they are crucial for confirming siRNA efficacy in a living organism. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">10. Cytotoxicity Assay \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Method: To ensure that the observed gene silencing is not due to cytotoxic effects, viability assays (e.g., MTT, Trypan Blue exclusion) can be used to confirm that the siRNA treatment does not cause significant cell death. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">     ●      Considerations: Always include proper controls to differentiate between silencing effects and toxic effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Using a combination of these methods provides a comprehensive understanding of \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002Fadmin\u002FGenCefe%20Biotech%20provides%20high-quality%20siRNA,%20miRNA,%20sgRNA,%20and%20custom%20RNA%20synthesis%20services.%20We%20can%20design%20and%20synthesize%20RNA%20Oligos%20of%20different%20lengths,%20different%20forms,%20and%20with%20various%20modification\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\"> silencing efficacy and ensures that both on-target and off-target effects are carefully evaluated. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; line-height: 1.5; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255);\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"background-color: transparent; color: rgb(70, 123, 150); transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; text-decoration: underline; font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"text-decoration: underline; font-family: Montserrat; font-size: 16px;\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-01-07 00:00:00","RNA Synthesis & Modifications—How to assess the silencing effect of siRNA","Assessing the silencing effect of siRNA is crucial to confirm its effectiveness in downregulating target gene expression. Several methods can be used, such as qPCR, Western Blot, ELISA, RNA-seq etc.","RNA Oligo, siRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:34:42","77,72,70,67,65","13,22",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":125,"categoryName":290,"title":324,"imgUrl":325,"content":326,"excerpt":59,"publishDate":327,"seoTitle":328,"seoDesc":329,"seoKeywords":330,"createDate":331,"sort":273,"relatedPostIds":332,"firstServiceProductId":29,"secondServiceProductIds":333,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},"What are the main applications of miRNA?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F14_20260630154221A117.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F14_20260630154226A118.png\" title=\"miRNA\" alt=\"miRNA\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">miRNA (microRNA) is a class of small non-coding RNA molecules that play a critical role in regulating gene expression. Due to its functions and characteristics, miRNA has been widely applied in various fields. Below are its main applications: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1. Gene Function Research \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Regulatory Studies: Analyzing the interaction between miRNA and target genes helps uncover gene regulatory networks and their roles in processes like cell differentiation, proliferation, and apoptosis. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Disease Mechanism Studies: Investigating miRNA dysregulation provides insights into the molecular mechanisms of diseases such as cancer, metabolic disorders, and cardiovascular conditions. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2. Disease Diagnosis \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Biomarkers: miRNAs are considered potential biomarkers for detecting various diseases due to their tissue-specific expression and high stability. For example, specific miRNAs in blood or urine can be used for early cancer or diabetes diagnosis. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Disease Classification: Unique miRNA expression profiles can assist in disease subtyping and classification. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3. Drug Development \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Targeted Therapy: Synthesized miRNA mimics or inhibitors can modulate disease-related miRNA expression, providing therapeutic approaches for conditions like cancer and viral infections. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Drug Sensitivity: miRNA expression levels may influence cellular responses to drugs, aiding in personalized treatment strategies. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4. Clinical Therapy \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      miRNA-Based Therapy: Therapies directly regulating miRNA expression, such as miRNA-delivering gene therapy, are being explored in clinical trials for cancer and genetic diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Regenerative Medicine: miRNAs can promote stem cell differentiation or regulate tissue repair, offering treatment potential for tissue injuries and degenerative diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5. Agricultural Applications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Crop Improvement: Regulating miRNA expression can enhance plant stress resistance (e.g., against diseases or drought) and yield. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Genetic Breeding: miRNA markers are used for screening and improving desirable traits in crops. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">6. Environmental and Toxicology Applications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Environmental Monitoring: Certain miRNAs respond sensitively to pollutants (e.g., heavy metals or chemical toxins), serving as early warning indicators of environmental pollution. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Toxicity Assessment: Changes in miRNA expression under toxic stress can be used to evaluate the potential hazards of chemicals. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">7. Tool Development \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Research Tools: miRNA inhibitors, fluorescent probes, and microarrays are widely used for basic and applied research. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Bioinformatics: Computational tools for predicting miRNA-target relationships guide experimental designs and analyses. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">In summary, miRNAs have broad prospects in life sciences and biotechnology. They play a significant role in disease diagnosis and treatment, agricultural improvement, and environmental monitoring, gaining increasing attention in these fields.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-01-21 00:00:00","RNA Synthesis & Modifications—Main applications of miRNA","miRNA (microRNA) is a class of small non-coding RNA molecules that play a critical role in regulating gene expression. They play a significant role in disease diagnosis and treatment, agricultural improvement, and environmental monitoring, gaining increasing attention in these fields.","RNA Oligo, siRNA, miRNA, microRNA, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:37:50","77,73,72,65,60","13,56",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":138,"categoryName":290,"title":335,"imgUrl":336,"content":337,"excerpt":59,"publishDate":338,"seoTitle":339,"seoDesc":340,"seoKeywords":341,"createDate":342,"sort":211,"relatedPostIds":343,"firstServiceProductId":29,"secondServiceProductIds":333,"relatedPost":20,"productService":20,"allSecondProductService":20,"twoSecondProductService":20},"What are the miRNA therapeutics currently in clinical and preclinical stages? ","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F18_20260630154651A125.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F18_20260630154656A126.png\" title=\"clinical and preclinical stages\" alt=\"clinical and preclinical stages\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">MicroRNA (miRNA) therapeutics are being actively developed, with several candidates progressing to clinical and preclinical stages. Below are examples from each category: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">miRNA Therapeutics in Clinical Stages \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.Miravirsen \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Function: A miR-122 inhibitor designed to treat hepatitis C virus (HCV) infection. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Progress: Developed by Santaris Pharma, Miravirsen was the first miRNA inhibitor to enter clinical trials and has reached Phase II. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Mechanism: Blocks miR-122, a host factor required for HCV replication, offering an innovative approach to antiviral therapy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.CDR132L \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Function: A miR-132 inhibitor targeting heart failure. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Progress: Developed by Cardior Pharmaceuticals, this therapy is undergoing clinical trials aimed at improving cardiac function by modulating miR-132. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Mechanism: Inhibits miR-132, which is associated with adverse cardiac remodeling and fibrosis. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">miRNA Therapeutics in Preclinical Stages \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.MRX34 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Function: A mimic of miR-34a, designed for cancer treatment. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Progress: Developed by Mirna Therapeutics, MRX34 initially entered Phase I clinical trials but was halted due to immune-related adverse effects. It is now undergoing further preclinical evaluation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Mechanism: Restores tumor-suppressive miR-34a activity to inhibit oncogenic pathways. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.TTX-MC138 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Function: Targets miR-10b for the treatment of breast and pancreatic cancers. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Progress: Developed by TransCode Therapeutics, TTX-MC138 has shown promising results in preclinical studies. It received FDA IND approval in 2024 and completed initial dosing in patients. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Mechanism: Suppresses miR-10b, which promotes cancer metastasis, thereby inhibiting tumor progression. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">In the clinical stage, miRNA therapeutics like Miravirsen and CDR132L are advancing in addressing HCV and heart failure, respectively, showcasing the potential of miRNA inhibitors. Meanwhile, preclinical candidates such as MRX34 and TTX-MC138 are making strides in cancer research. Although promising, miRNA therapies face challenges like delivery efficiency and safety, which must be overcome to achieve broader clinical success.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-02-21 00:00:00","RNA Synthesis & Modifications—miRNA therapeutics currently in clinical and preclinical stages"," In the clinical stage, miRNA therapeutics like Miravirsen and CDR132L are advancing in addressing HCV and heart failure, respectively, showcasing the potential of miRNA inhibitors.","RNA Oligo, miRNA, microRNA, miRNA inhibitors, miRNA mimics, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:47:58","58,56,55,54",{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":29,"title":62,"excerpt":345,"content":346,"seoTitle":347,"seoDesc":348,"seoKeywords":349,"sort":350,"createDate":351,"secondColor":352,"showOrderPic":5,"homeState":29,"homePic":353,"homeTitle":354,"homeDesc":355,"homeSort":350,"orderDesc":356,"orderUrl":357,"email":14,"phone":15,"onlineFormUrl":357,"serviceFeatureList":20,"productServiceSubList":20},"GenCefe Biotech provides high-quality siRNA , miRNA , sgRNA , and custom RNA synthesis and modification. We can design and synthesize RNA of different lengths, different forms, and with various modifications.","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fgencefebio.com\u002FproductsAndservices\u002F1-RNAi_Products_RNA_Synthesis.html\" style=\"font-family: Montserrat; color: rgb(0, 112, 192);\">\u003Cstrong>RNA synthesis\u003C\u002Fstrong>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services, including siRNA, miRNA, sgRNA, and custom RNA oligonucleotide synthesis. We support both customer-designed sequences and custom RNA projects with flexible options for sequence length, modifications, and synthesis specifications. Production scales range from nmol and μmol quantities to larger-scale manufacturing, supporting diverse research and diagnostic development needs. Supported by ISO 9001 and ISO 13485 certified quality management systems, GenCefe delivers reliable RNA products, comprehensive QC documentation, and consistent project support.\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255); line-height: 1.75em;\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px; color: rgb(54, 96, 146);\">RNA Synthesis Service Specifications:\u003C\u002Fspan>\u003Cspan style=\"color: rgb(79, 129, 189);\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px;\">\u003C\u002Fspan>\u003Cspan style=\"font-size: 16px; font-family: Montserrat; font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box;\">\u003C\u002Fspan>\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The following table summarizes our RNA synthesis service options, specifications, and ordering details:\u003C\u002Fspan>\u003C\u002Fp>\u003Ctable>\u003Ctbody style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctr class=\"firstRow\" style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Product Name\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Length\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Amount\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Purification Method\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Turnaround Time (days)*\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Order\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">RNA oligo\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">HPLC\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(0, 0, 0); border-right-color: rgb(0, 0, 0); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Please fill out the \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo order form\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">  and send it via email to \u003C\u002Fspan>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo@gencefebio.com\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Modified\u002FLabeled RNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol, to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Large-scale RNA Synthesis \u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">OD, nmol,\u003Cbr\u002F>milligram, gram\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Get a Quote\u003C\u002Fspan>\u003C\u002Fa>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>\u003Cem style=\"color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px;\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">* Turnaround time refers to the estimated time required for order processing, production, and shipment. Actual delivery times may vary depending on the destination and courier transit time.\u003C\u002Fspan>\u003C\u002Fem>\u003C\u002Fp>","RNA Synthesis | Fast Delivery & 50K+ siRNA Sets-GenCefe","GenCefe provides siRNA, miRNA, sgRNA, pegRNA, and custom RNA synthesis and modification services for RNAi, gene editing, and gene regulation.","RNA Synthesis, custom RNA oligo, RNA oligo synthesis, siRNA, miRNA, sgRNA, Antisense oligo",88,"2024-10-24 14:13:06","#48bfea","https:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2025\u002F04\u002F20\u002FRNA合成_蓝_20250420143026A002.png","RNA Synthesis","Custom synthesis and modification. 50,000+ pre-designed siRNA sets","Advance your RNA research with flexible RNA synthesis services, expert support, and dependable project execution.","https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM",[359,360,361,362,363,364,365],{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":65,"parentId":29,"title":66,"subTitle":67,"excerpt":68,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":70,"parentId":29,"title":71,"subTitle":72,"excerpt":73,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":29,"newState":5,"type":74,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":76,"parentId":29,"title":77,"subTitle":78,"excerpt":79,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":81,"parentId":29,"title":82,"subTitle":83,"excerpt":84,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":86,"parentId":29,"title":87,"subTitle":88,"excerpt":89,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":29,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":91,"parentId":29,"title":92,"subTitle":59,"excerpt":93,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":95,"parentId":29,"title":96,"subTitle":59,"excerpt":97,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},[367,368],{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":65,"parentId":29,"title":66,"subTitle":67,"excerpt":68,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20},{"createBy":20,"createTime":20,"updateBy":20,"updateTime":20,"remark":20,"id":91,"parentId":29,"title":92,"subTitle":59,"excerpt":93,"content":20,"seoTitle":20,"seoDesc":20,"seoKeywords":20,"createDate":20,"orderDesc":20,"orderUrl":20,"email":20,"phone":20,"onlineFormUrl":20,"sort":20,"hotState":5,"newState":5,"type":30,"customerTestimonials":20,"productCatalog":20,"relatedTitles":20,"productService":20,"customerTestimonialsList":20,"relatedTitlesList":20,"serviceFeatureSubList":20,"productCatalogList":20}]