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Despite their similarities, they differ in origin, mechanism, and application.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Ctable cellspacing=\"0\">\u003Ctbody style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctr class=\"firstRow\" style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); text-align: center; border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cbr\u002F>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">miRNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">siRNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Origin\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Endogenously encoded; processed from primary miRNA (pri-miRNA) to mature miRNA.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Often exogenous (synthetic or viral); processed from long double-stranded RNA (dsRNA).\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Structure\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Single-stranded with imperfectly paired hairpin structures.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Double-stranded RNA with perfect complementarity.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Mechanism of Action\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(204, 204, 204); border-right-color: rgb(204, 204, 204); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Binds to partially complementary sequences in the 3' UTR of mRNA, leading to translational repression or degradation.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Binds to perfectly complementary sequences, inducing target mRNA cleavage and degradation.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Target Specificity\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Broad target range; regulates multiple genes due to partial complementarity.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Highly specific; targets a single mRNA due to perfect base pairing.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Biological Function\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Regulates endogenous gene expression; involved in development, cell differentiation, and stress responses.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Acts as a defense mechanism against viruses and transposable elements.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Applications\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Biomarkers for disease diagnostics and prognostics; potential for modulating multiple pathways in therapy.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd valign=\"top\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid rgb(204, 204, 204); border-right: 1px solid rgb(204, 204, 204); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Research tools for gene silencing; therapeutics for precise gene targeting (e.g., ONPATTRO).\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">While both miRNA and siRNA are crucial players in RNA interference, they differ significantly in their origin, targeting mechanisms, and functional roles. miRNAs are endogenous regulators with broader, less specific effects, whereas siRNAs are more specific tools for precise gene silencing, making them complementary in research and therapeutic applications.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-02-27 00:00:00","RNA Synthesis & Modifications—Differences between miRNA and siRNA","miRNAs are endogenous regulators with broader, less specific effects, whereas siRNAs are more specific tools for precise gene silencing, making them complementary in research and therapeutic applications."," RNA Oligo, miRNA, microRNA, siRNA, RNAi, RNA interference, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:49:36","61,60,59,58","13,56",[301,311,321,331],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":112,"categoryName":289,"title":302,"imgUrl":303,"content":304,"excerpt":90,"publishDate":305,"seoTitle":306,"seoDesc":307,"seoKeywords":308,"createDate":309,"sort":207,"relatedPostIds":310,"firstServiceProductId":61,"secondServiceProductIds":299,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},"What are the main challenges in the development of small nucleic acid drugs?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F05_20260630144340A098.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F05_20260630144521A099.png\" title=\"Small nucleic acid drug, custom RNA synthesis\" alt=\"Small nucleic acid drug, custom RNA synthesis\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Despite their therapeutic potential, small nucleic acid drugs face several significant challenges in development: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●     Delivery Efficiency: Difficulty in delivering nucleic acids to specific tissues and crossing cellular membranes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●     Stability: Prone to degradation by nucleases, requiring chemical modifications for stability. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●     Immunogenicity: Risk of triggering innate immune responses, especially unmodified sequences. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●     Off-Target Effects: Potential for unintended gene silencing or activation, requiring stringent sequence design. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●     Manufacturing Complexity: High production costs and the need for precise synthesis and purification methods. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●     Regulatory Hurdles: Limited precedent in regulatory pathways for novel small nucleic acid drugs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Addressing these challenges requires innovations in delivery systems, chemical modifications, and design strategies, helping advance small nucleic acid drugs toward broader clinical applications. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-17 00:00:00","RNA Synthesis & Modifications—Challenges in the development of small nucleic acid drugs","Addressing these challenges requires innovations in delivery systems, chemical modifications, and design strategies, helping advance small nucleic acid drugs toward broader clinical applications.","RNA Oligo, siRNA, miRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis","2025-04-28 17:04:53","73,72,71,70,69",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":117,"categoryName":289,"title":312,"imgUrl":313,"content":314,"excerpt":90,"publishDate":315,"seoTitle":316,"seoDesc":317,"seoKeywords":318,"createDate":319,"sort":182,"relatedPostIds":310,"firstServiceProductId":61,"secondServiceProductIds":320,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},"What are the common delivery strategies for small nucleic acid drugs?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F06_20260630144848A104.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F06_20260630144629A100.png\" title=\"Small nucleic acid drug, custom RNA synthesis, drug delivery\" alt=\"Small nucleic acid drug, custom RNA synthesis, drug delivery\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Several delivery strategies are employed to overcome the challenges of nucleic acid stability, cellular uptake, and tissue targeting for small nucleic acid drugs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Liposomes and Lipid Nanoparticles (LNPs): Encapsulate nucleic acids in lipid-based carriers to improve stability and facilitate cell membrane fusion for delivery. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Polymeric Nanoparticles: Utilize biocompatible polymers (e.g., polyethyleneimine, chitosan) to form nanoparticles that protect nucleic acids and enhance cellular uptake. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Viral Vectors: Modified viruses (e.g., adenoviruses, lentiviruses) are used to deliver nucleic acids, ensuring efficient gene transfer. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Exosome-Based Delivery: Use natural exosomes as carriers to facilitate targeted delivery and immune evasion. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Cationic Lipid and Polymers: These positively charged molecules bind to negatively charged nucleic acids, enhancing delivery and uptake by cells. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Targeted Delivery Systems: Surface modifications (e.g., antibodies, peptides) on delivery vehicles to selectively target specific cells or tissues. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">These strategies focus on improving the bioavailability, targeting, and cellular uptake of small nucleic acid drugs for effective therapy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">.\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\"> We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-19 00:00:00","RNA Synthesis & Modifications—Delivery strategies for small nucleic acid drugs","Several delivery strategies are employed to overcome the challenges of nucleic acid stability, cellular uptake, and tissue targeting for small nucleic acid drugs.","RNA Oligo, siRNA, miRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis, drug delivery","2025-04-28 17:05:53","13,60",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":31,"categoryName":289,"title":322,"imgUrl":323,"content":324,"excerpt":90,"publishDate":325,"seoTitle":326,"seoDesc":327,"seoKeywords":328,"createDate":329,"sort":231,"relatedPostIds":330,"firstServiceProductId":61,"secondServiceProductIds":320,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},"What are the common types of modifications for small nucleic acids and their main functions?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F07_20260630144718A101.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F07_20260630144724A102.png\" title=\" RNA modifications, custom RNA synthesis\" alt=\" RNA modifications, custom RNA synthesis\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Various modifications are applied to small nucleic acids to enhance their stability, reduce immunogenicity, and improve targeting. Below are the most commonly used modifications and their primary functions: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Phosphorothioate (PS) Modification: Substitution of one of the non-bridging oxygen atoms in the phosphodiester backbone with sulfur. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Increases stability by protecting against nuclease degradation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    2'-O-Methyl (2'-OMe) Modification: Addition of a methyl group at the 2' position of the ribose sugar. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Enhances resistance to nuclease activity and reduces immune activation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Locked Nucleic Acid (LNA): Modification of the ribose sugar to "lock" the sugar in a particular conformation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Improves hybridization affinity and stability, especially for ASOs and miRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Fluorescent Labels: Attachment of fluorescent molecules to the oligonucleotide. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Used for tracking, imaging, and studying the distribution of nucleic acids. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Cholesterol Conjugation: Adding a cholesterol group to the oligonucleotide. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Enhances cellular uptake and promotes delivery across cell membranes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Polyethylene Glycol (PEG) Conjugation: Attachment of PEG chains to the nucleic acid. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●   Main Function: Increases solubility, reduces immunogenicity, and prolongs circulation time in vivo. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">These modifications are strategically used to optimize the pharmacokinetics, stability, and therapeutic efficacy of small nucleic acids.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-24 00:00:00","RNA Synthesis & Modifications—RNA modifications and their functions","Various modifications are applied to small nucleic acids to enhance their stability, reduce immunogenicity, and improve targeting, such as PS, 2'-OMe, LNA, etc.","RNA Oligo, siRNA, miRNA, Antisense Oligo, RNA modifications, custom RNA synthesis","2025-04-28 17:06:54","78,75,73,70,68",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":125,"categoryName":289,"title":332,"imgUrl":333,"content":334,"excerpt":90,"publishDate":335,"seoTitle":336,"seoDesc":337,"seoKeywords":338,"createDate":339,"sort":284,"relatedPostIds":340,"firstServiceProductId":61,"secondServiceProductIds":320,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},"How does GalNAc help in the delivery of small nucleic acid drugs?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F08_20260630144912A106.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F08_20260630144908A105.png\" title=\"GalNAc, drug delivery, custom RNA synthesis\" alt=\"GalNAc, drug delivery, custom RNA synthesis\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GalNAc plays a crucial role in enhancing the targeted delivery of small nucleic acid drugs, particularly for liver-targeted therapies. Here's how it works: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Specific Binding to Liver Cells: GalNAc specifically binds to the asialoglycoprotein receptors (ASGPR) that are highly expressed on hepatocytes (liver cells). This binding facilitates the selective uptake of nucleic acid drugs by liver cells, ensuring targeted delivery. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Increased Cellular Uptake: By attaching GalNAc to small nucleic acids (such as siRNA or ASOs), the drug is more efficiently internalized into liver cells via receptor-mediated endocytosis. This enhances the bioavailability of the drug in the liver. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Improved Pharmacokinetics: GalNAc conjugation increases the stability of the drug in circulation, allowing it to remain in the bloodstream longer before being cleared. This extended half-life improves the therapeutic window, increasing the drug's effectiveness. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Reduced Off-Target Effects: The liver-specific targeting of GalNAc reduces the likelihood of the drug affecting other tissues, minimizing off-target effects and systemic toxicity. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Enhanced Efficacy: The precise delivery to liver cells allows for higher local concentrations of the drug, leading to more efficient gene silencing (for RNAi drugs) or modulation (for ASOs) in liver-related diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">By directing the therapeutic nucleic acid to the liver specifically, GalNAc enables small nucleic acid drugs to achieve higher therapeutic efficacy while minimizing side effects, particularly for diseases affecting the liver. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">,\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\"> and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-26 00:00:00","RNA Synthesis & Modifications—GalNAc and small nucleic acid drug delivery","By directing the therapeutic nucleic acid to the liver specifically, GalNAc enables small nucleic acid drugs to achieve higher therapeutic efficacy while minimizing side effects, particularly for diseases affecting the liver.","RNA Modifications, siRNA, miRNA, Antisense Oligo, GalNAc, drug delivery, custom RNA synthesis","2025-04-28 17:08:09","78,76,71,70,57",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":61,"title":93,"excerpt":342,"content":343,"seoTitle":344,"seoDesc":345,"seoKeywords":346,"sort":347,"createDate":348,"secondColor":349,"showOrderPic":5,"homeState":61,"homePic":350,"homeTitle":351,"homeDesc":352,"homeSort":347,"orderDesc":353,"orderUrl":354,"email":48,"phone":49,"onlineFormUrl":354,"serviceFeatureList":8,"productServiceSubList":8},"GenCefe Biotech provides high-quality siRNA , miRNA , sgRNA , and custom RNA synthesis and modification. We can design and synthesize RNA of different lengths, different forms, and with various modifications.","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fgencefebio.com\u002FproductsAndservices\u002F1-RNAi_Products_RNA_Synthesis.html\" style=\"font-family: Montserrat; color: rgb(0, 112, 192);\">\u003Cstrong>RNA synthesis\u003C\u002Fstrong>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services, including siRNA, miRNA, sgRNA, and custom RNA oligonucleotide synthesis. We support both customer-designed sequences and custom RNA projects with flexible options for sequence length, modifications, and synthesis specifications. Production scales range from nmol and μmol quantities to larger-scale manufacturing, supporting diverse research and diagnostic development needs. Supported by ISO 9001 and ISO 13485 certified quality management systems, GenCefe delivers reliable RNA products, comprehensive QC documentation, and consistent project support.\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255); line-height: 1.75em;\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px; color: rgb(54, 96, 146);\">RNA Synthesis Service Specifications:\u003C\u002Fspan>\u003Cspan style=\"color: rgb(79, 129, 189);\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px;\">\u003C\u002Fspan>\u003Cspan style=\"font-size: 16px; font-family: Montserrat; font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box;\">\u003C\u002Fspan>\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The following table summarizes our RNA synthesis service options, specifications, and ordering details:\u003C\u002Fspan>\u003C\u002Fp>\u003Ctable>\u003Ctbody style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctr class=\"firstRow\" style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Product Name\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Length\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Amount\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Purification Method\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Turnaround Time (days)*\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Order\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">RNA oligo\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">HPLC\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(0, 0, 0); border-right-color: rgb(0, 0, 0); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Please fill out the \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo order form\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">  and send it via email to \u003C\u002Fspan>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo@gencefebio.com\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Modified\u002FLabeled RNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol, to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Large-scale RNA Synthesis \u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">OD, nmol,\u003Cbr\u002F>milligram, gram\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Get a Quote\u003C\u002Fspan>\u003C\u002Fa>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>\u003Cem style=\"color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px;\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">* Turnaround time refers to the estimated time required for order processing, production, and shipment. Actual delivery times may vary depending on the destination and courier transit time.\u003C\u002Fspan>\u003C\u002Fem>\u003C\u002Fp>","RNA Synthesis | Fast Delivery & 50K+ siRNA Sets-GenCefe","GenCefe provides siRNA, miRNA, sgRNA, pegRNA, and custom RNA synthesis and modification services for RNAi, gene editing, and gene regulation.","RNA Synthesis, custom RNA oligo, RNA oligo synthesis, siRNA, miRNA, sgRNA, Antisense oligo",88,"2024-10-24 14:13:06","#48bfea","https:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2025\u002F04\u002F20\u002FRNA合成_蓝_20250420143026A002.png","RNA Synthesis","Custom synthesis and modification. 50,000+ pre-designed siRNA sets","Advance your RNA research with flexible RNA synthesis services, expert support, and dependable project execution.","https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM",[356,357,358,359,360,361,362],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":96,"parentId":61,"title":97,"subTitle":98,"excerpt":99,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":101,"parentId":61,"title":102,"subTitle":103,"excerpt":104,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":61,"newState":5,"type":105,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":107,"parentId":61,"title":108,"subTitle":109,"excerpt":110,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":112,"parentId":61,"title":113,"subTitle":114,"excerpt":115,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":117,"parentId":61,"title":118,"subTitle":119,"excerpt":120,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":61,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":31,"parentId":61,"title":122,"subTitle":90,"excerpt":123,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":125,"parentId":61,"title":126,"subTitle":90,"excerpt":127,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},[364,365],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":96,"parentId":61,"title":97,"subTitle":98,"excerpt":99,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":107,"parentId":61,"title":108,"subTitle":109,"excerpt":110,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8}]