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solubility.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":179,"parentId":167,"title":180,"subTitle":47,"excerpt":181,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},53,"Mammalian Cell Expression","GenCefe’s mammalian expression systems (CHO and HEK293) produce recombinant proteins and antibodies with proper post-translational modifications for functionally relevant applications.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":183,"parentId":167,"title":184,"subTitle":47,"excerpt":185,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},54,"Insect Cell\u002FBaculovirus Expression","The insect cell\u002Fbaculovirus system enables eukaryotic protein expression with complex folding and post-translational modifications, suitable for research and development use.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":187,"parentId":167,"title":188,"subTitle":47,"excerpt":189,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},55,"Yeast Expression","Yeast-based expression systems provide a cost-effective option for recombinant protein production, supported by sequence and expression optimization strategies.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":191,"title":192,"excerpt":8,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"sort":8,"createDate":8,"secondColor":8,"showOrderPic":8,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"serviceFeatureList":8,"productServiceSubList":193},7,"Peptide Synthesis & Modification",[194,198,202,206,210,214,218],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":195,"parentId":191,"title":196,"subTitle":47,"excerpt":197,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},19,"Custom Peptide Synthesis","GenCefe Biotech uses solid- and liquid-phase peptide synthesis to deliver high-quality custom, modified, labeled, cyclized peptides, glycopeptides, and libraries.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":199,"parentId":191,"title":200,"subTitle":47,"excerpt":201,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},18,"Modified\u002FFluorescent Labeled Peptides","GenCefe provides over 300 different peptide modification groups, including: N-\u002FC-terminal modifications, fluorescent labeling, cyclic peptides, biotin labeling, etc.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":203,"parentId":191,"title":204,"subTitle":47,"excerpt":205,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},17,"Stable Isotope-Labeled Peptides","GenCefe offers custom stable isotope-labeled peptides by incorporating isotope-labeled amino acids like C and N directly during synthesis, labeling the entire peptide chain.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":207,"parentId":191,"title":208,"subTitle":47,"excerpt":209,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},44,"Cyclic Peptide Synthesis","GenCefe Biotech provides clyclic peptide synthesis services, including Stapled Peptides, Cyclization at side chain, Head-to-tail cyclization, etc.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":211,"parentId":191,"title":212,"subTitle":47,"excerpt":213,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},45,"Glycopeptides","GenCefe Biotech provides glycosylation modification services, producing glycopeptides with N-linked and O-linked types to enhance protein stability, activity, and cell signaling.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":215,"parentId":191,"title":216,"subTitle":47,"excerpt":217,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},46,"Peptide Libraries","GenCefe Biotech provides a variety of peptide library synthesis services, including over lapping libraries, random libraries, amino acid scanning libraries, etc.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":219,"parentId":191,"title":220,"subTitle":47,"excerpt":221,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},47,"Catalog Peptides","GenCefe Biotech offers over 2,000 catalog peptides covering popular research areas, available from stock.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":223,"title":224,"excerpt":8,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"sort":8,"createDate":8,"secondColor":8,"showOrderPic":8,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"serviceFeatureList":8,"productServiceSubList":225},4,"Synthetic DNA Libraries",[226,230,234,238,242],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":227,"parentId":223,"title":228,"subTitle":47,"excerpt":229,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},30,"Site-Directed Mutagenesis Libraries","Site-directed mutagenesis libraries introduce defined amino acid substitutions at selected positions, enabling structure–function studies, protein engineering, and antibody optimization.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":231,"parentId":223,"title":232,"subTitle":47,"excerpt":233,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},21,"Random Mutagenesis Libraries","Random mutagenesis libraries generate diverse sequence variants through random nucleotide mutations, making them ideal for directed evolution and functional discovery.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":235,"parentId":223,"title":236,"subTitle":47,"excerpt":237,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},31,"Degenerate (Saturation Mutagenesis) Libraries","Degenerate (saturation mutagenesis) libraries introduce NNK or NNN codons at selected positions to generate broad amino acid diversity for protein engineering and affinity maturation.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":239,"parentId":223,"title":240,"subTitle":47,"excerpt":241,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},32,"Controlled (Trimer) Libraries","Controlled (Trimer) libraries use predefined trinucleotide building blocks to precisely control amino acid diversity while reducing codon redundancy for efficient library design.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":243,"parentId":223,"title":244,"subTitle":47,"excerpt":245,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},33,"CRISPR sgRNA Libraries ","CRISPR sgRNA libraries enable high-throughput functional screening for target discovery, functional genomics, and phenotype-based studies.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":247,"title":248,"excerpt":8,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"sort":8,"createDate":8,"secondColor":8,"showOrderPic":8,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"serviceFeatureList":8,"productServiceSubList":249},8,"Reagents & Kits",[],{"msg":4,"code":5,"data":251},{"companyName":252,"shortCompanyName":253,"title":253,"subTitle":254,"siteUrl":255,"siteDescription":256,"siteKeywords":257,"beiAnInfo":258,"email":259,"phone":260,"address":261},"GENCEFE Biotech (Wuxi, China) ","GenCefe","Your Reliable Partner of Oligo, Gene, Peptide, Protein ","https:\u002F\u002Fwww.gencefebio.com\u002F","GenCefe specializes in DNA, RNA, gene, peptide, and protein synthesis. Combined with our advanced AI-assisted design platform, we provide high-quality services for synthetic biology, molecular diagnostics, and drug discovery.","gene synthesis, oligo synthesis, RNA synthesis, DNA synthesis, peptide synthesis, protein expression and purification, gencefe, gencefe biotech","ICP备案：XXXXXXX\r\n苏公网安备32021402001785号","gene@gencefebio.com","+1 408-828-0438","17800 Castleton St, Ste 665, City of industry, CA 91748, USA",{"msg":4,"code":5,"data":263},[264,272,276,279,282,284],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":9,"title":265,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":266,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":267,"productService":8},"Oligonucleotide Drug Synthesis",90,[268,270],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":9,"orderNum":8,"ancestors":8,"id":195,"title":269,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":266,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},"Oligonucleotide Synthesis and Modifications",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":9,"orderNum":8,"ancestors":8,"id":138,"title":271,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":35,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},"Oligonucleotide biological evaluation platform",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":273,"title":274,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":275,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},14,"Gene&Genome Editing",80,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":277,"title":278,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":122,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},15,"Synthetic Biology",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":280,"title":281,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":79,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},16,"Antibody Drug Discovery",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":203,"title":283,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":35,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},"IVD Raw Material",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":199,"title":285,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":286,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},"Vaccine and Novel Therapy",40,{"msg":4,"code":5,"data":288},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":96,"categoryName":289,"title":290,"imgUrl":291,"content":292,"excerpt":47,"publishDate":293,"seoTitle":294,"seoDesc":295,"seoKeywords":296,"createDate":297,"sort":157,"relatedPostIds":298,"firstServiceProductId":17,"secondServiceProductIds":299,"relatedPost":300,"productService":347,"allSecondProductService":361,"twoSecondProductService":369},"RNA & Nucleic Acid Drug","What are the key considerations in siRNA design?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F10_20260630145140A109.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F10_20260630145147A110.png\" title=\"key considerations\" alt=\"key considerations\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Designing effective \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> involves several important factors to ensure high silencing efficiency, specificity, and minimal off-target effects. Below are the key considerations when designing siRNA: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1. Target Sequence Selection \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Select an Efficient Target Region: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Choose a target sequence that is highly conserved among species and is ideally located in the 3' untranslated region (UTR) or coding region to maximize gene silencing. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Avoid Off-Target Sequences: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Ensure that the siRNA sequence does not significantly match other genes in the genome to reduce off-target effects. Tools like BLAST can be used to assess off-target potential. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Preferably Avoid Sequence with Secondary Structures: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Select target sequences that do not form strong secondary structures (such as hairpins), as these can hinder the binding of the siRNA to the mRNA. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2. siRNA Duplex Design \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Guide and Passenger Strand Balance: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The guide strand is the one that binds to the target mRNA, while the passenger strand is degraded. Ensure that the guide strand is selected from the most potent position, usually the middle of the target sequence. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    The guide strand should have a 5' phosphate, and the passenger strand should have a 3' overhang for efficient loading into the RNA-induced silencing complex (RISC). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Strand Stability: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Ensure a proper balance in the melting temperature (Tm) between the two strands. The 5' end of the guide strand should ideally be more stable than the passenger strand to promote unwinding of the duplex and incorporation of the guide strand into RISC. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3. siRNA Length \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Typically 19-23 Nucleotides: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">siRNA is typically designed to be 19-23 base pairs long. This length is optimal for efficient cleavage by the RNA-induced silencing complex (RISC) and minimizes the risk of immune activation. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4. Chemical Modifications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Phosphorothioate Backbone Modification:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Introduce phosphorothioate modifications at the 3' and\u002For 5' ends of the siRNA to increase stability against nucleases in serum and cellular environments. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    2'-O-Methyl and 2'-Fluoro Modifications: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Use these modifications to protect the siRNA from degradation and reduce activation of innate immune responses by Toll-like receptors (TLRs). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Cholesterol Conjugation (for in vivo): \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Conjugate cholesterol to the siRNA (typically at the 3' end) to enhance cellular uptake, particularly for liver-targeted siRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5. GC Content \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    GC Content of 30-50%: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Ideally, the GC content of the siRNA should be balanced to ensure optimal stability and efficient hybridization with the target mRNA. Avoid sequences that are too rich in GC, as they may form secondary structures. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">6. Avoid Sequence Homology with Other Genes \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Minimize Homology with Off-Target Genes: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Ensure that the siRNA sequence does not have significant homology with unintended genes to minimize off-target silencing effects. This can be assessed through bioinformatics tools to check for off-target sequences. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">7. Avoid Immunostimulatory Sequences \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Avoid PAMP Motifs: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Avoid sequences that might trigger immune responses (e.g., patterns recognized by Toll-like receptors or other immune sensors). This can be especially critical for in vivo applications where systemic immune activation could limit efficacy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">8. 5’ and 3’ End Modifications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    3' Overhang: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">For efficient incorporation into the RISC complex, siRNAs typically have a 3' overhang of 2–3 nucleotides. This facilitates the unwinding of the duplex and guide strand loading. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    5' Phosphate Group: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The guide strand should have a 5' phosphate, which is essential for RISC binding and mRNA cleavage. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">9. Secondary Structure Considerations \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Minimize Hairpin or G-Quadruplex Formation: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Avoid sequences that form strong secondary structures, such as hairpins, as these can inhibit efficient siRNA-mRNA hybridization and reduce silencing efficacy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">10. Target Gene Validation \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Validate Target mRNA Structure: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Before siRNA design, ensure that the target mRNA is accessible and that there are no structural elements (like G-quadruplexes) that would prevent siRNA binding. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Efficient \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> design involves a careful balance between target specificity, stability, and minimizing immune responses or off-target effects. Key considerations include selecting optimal target sequences, modifying the siRNA backbone for stability, ensuring proper strand orientation and length, and using chemical modifications to improve pharmacokinetics, particularly for in vivo applications. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-01-02 00:00:00","RNA Synthesis & Modifications—Key considerations in siRNA design","Key considerations of siRNA design include selecting optimal target sequences, modifying the siRNA backbone for stability, ensuring proper strand orientation and length, and using chemical modifications to improve pharmacokinetics, particularly for in vivo applications.","RNA Oligo, siRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis, siRNA design","2025-04-30 16:33:39","77,69,62,59,57","13,22",[301,312,322,334],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":74,"categoryName":289,"title":302,"imgUrl":303,"content":304,"excerpt":47,"publishDate":305,"seoTitle":306,"seoDesc":307,"seoKeywords":308,"createDate":309,"sort":142,"relatedPostIds":310,"firstServiceProductId":17,"secondServiceProductIds":311,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},"What are the common delivery strategies for small nucleic acid drugs?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F06_20260630144848A104.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F06_20260630144629A100.png\" title=\"Small nucleic acid drug, custom RNA synthesis, drug delivery\" alt=\"Small nucleic acid drug, custom RNA synthesis, drug delivery\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Several delivery strategies are employed to overcome the challenges of nucleic acid stability, cellular uptake, and tissue targeting for small nucleic acid drugs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Liposomes and Lipid Nanoparticles (LNPs): Encapsulate nucleic acids in lipid-based carriers to improve stability and facilitate cell membrane fusion for delivery. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Polymeric Nanoparticles: Utilize biocompatible polymers (e.g., polyethyleneimine, chitosan) to form nanoparticles that protect nucleic acids and enhance cellular uptake. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Viral Vectors: Modified viruses (e.g., adenoviruses, lentiviruses) are used to deliver nucleic acids, ensuring efficient gene transfer. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Exosome-Based Delivery: Use natural exosomes as carriers to facilitate targeted delivery and immune evasion. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Cationic Lipid and Polymers: These positively charged molecules bind to negatively charged nucleic acids, enhancing delivery and uptake by cells. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Targeted Delivery Systems: Surface modifications (e.g., antibodies, peptides) on delivery vehicles to selectively target specific cells or tissues. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">These strategies focus on improving the bioavailability, targeting, and cellular uptake of small nucleic acid drugs for effective therapy. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">.\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\"> We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-19 00:00:00","RNA Synthesis & Modifications—Delivery strategies for small nucleic acid drugs","Several delivery strategies are employed to overcome the challenges of nucleic acid stability, cellular uptake, and tissue targeting for small nucleic acid drugs.","RNA Oligo, siRNA, miRNA, Antisense Oligo, Small nucleic acid drug, custom RNA synthesis, drug delivery","2025-04-28 17:05:53","73,72,71,70,69","13,60",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":91,"categoryName":289,"title":313,"imgUrl":314,"content":315,"excerpt":47,"publishDate":316,"seoTitle":317,"seoDesc":318,"seoKeywords":319,"createDate":320,"sort":9,"relatedPostIds":321,"firstServiceProductId":17,"secondServiceProductIds":311,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},"Are there any approved drugs on the market that use GalNAc for delivery? ","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F09_20260630145029A107.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F09_20260630145034A108.png\" title=\"GalNAc\" alt=\"GalNAc\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Yes, several RNA-based therapeutics using GalNAc conjugation have been approved for clinical use, particularly for liver-targeted therapies. Some of the approved drugs that utilize GalNAc for targeted delivery include: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Patisiran (siRNA): Targets transthyretin (TTR) to treat hereditary transthyretin-mediated amyloidosis. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Approval Year: 2018 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Regulatory Body: FDA \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      GalNAc Use: Patisiran uses GalNAc conjugation to enhance liver-specific delivery of the siRNA. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Givosiran (siRNA): Targets aminolevulinate synthase 1 (ALAS1) to treat acute hepatic porphyria. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Approval Year: 2019 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Regulatory Body: FDA \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      GalNAc Use: Givosiran also utilizes GalNAc conjugation to target delivery to liver cells. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">   ●    Vupanorsen (ASO): Aiming to reduce apoC-III for treating hypertriglyceridemia. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Approval Year: 2024 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Regulatory Body: EMA (European Medicines Agency) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      GalNAc Use: Vupanorsen uses GalNAc for liver-targeted delivery of antisense oligonucleotides. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">These drugs demonstrate how GalNAc conjugation is effectively used to enhance the delivery and therapeutic impact of small nucleic acids, particularly in liver-targeted treatments. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F20.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">siRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F21.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">miRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">, \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F22.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">sgRNA\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, and \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FRNASynthesis\u002F10.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom RNA synthesis\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-12-31 00:00:00","RNA Synthesis & Modifications—Approved drugs that use GalNAc for delivery"," Several RNA-based therapeutics using GalNAc conjugation have been approved for clinical use, particularly for liver-targeted therapies, such as Patisiran (siRNA), Givosiran (siRNA), and Vupanorsen (ASO).","RNA Modifications, siRNA, miRNA, Antisense Oligo, GalNAc, drug delivery, custom RNA synthesis","2025-04-30 16:32:08","72,67,66,61,59",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":323,"categoryName":289,"title":324,"imgUrl":325,"content":326,"excerpt":47,"publishDate":327,"seoTitle":328,"seoDesc":329,"seoKeywords":330,"createDate":331,"sort":280,"relatedPostIds":332,"firstServiceProductId":17,"secondServiceProductIds":333,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},69,"What is the current progress in miRNA therapeutics research?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F16_20260630154431A121.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F16_20260630154437A122.png\" title=\"miRNA therapeutics research\" alt=\"miRNA therapeutics research\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">MicroRNA (miRNA) therapeutics research has achieved significant milestones, highlighting its potential for treating complex diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.Therapeutic Applications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      miRNAs have been identified as key regulators in various diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and metabolic syndromes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Therapeutic strategies involve miRNA mimics to replenish downregulated miRNAs and miRNA inhibitors (antagomiRs) to block the activity of overexpressed miRNAs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.Clinical Trials \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Multiple miRNA-based drugs have entered clinical trials. Examples include: \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      MRG-110, targeting miRNA-92a to promote angiogenesis in ischemic diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      RG-012, designed to inhibit miRNA-21 for treating Alport syndrome. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3.Innovative Delivery Systems \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Advanced delivery methods, such as lipid nanoparticles (LNPs), exosome-based carriers, and viral vectors, have enhanced the stability and cellular uptake of miRNA therapeutics. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Tissue-specific targeting has been a primary goal to reduce systemic side effects. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4.Chemical Modifications \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Chemical enhancements, such as locked nucleic acids (LNAs), 2'-O-methylation, and phosphorothioates, have improved the stability, efficacy, and safety of miRNA drugs. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5.Biomarker Development \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      miRNAs are being developed as diagnostic and prognostic biomarkers for diseases such as cancer and cardiovascular conditions, facilitating personalized medicine approaches. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Recent advancements in miRNA therapeutics demonstrate their potential for treating previously untreatable diseases. Key innovations in delivery technologies, chemical modifications, and biomarker applications are paving the way for miRNA-based therapies to transition from experimental to clinical use.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-02-13 00:00:00","RNA Synthesis & Modifications—Progress in miRNA therapeutics research","Recent advancements in miRNA therapeutics demonstrate their potential for treating previously untreatable diseases. Key innovations in delivery technologies, chemical modifications, and biomarker applications are paving the way for miRNA-based therapies to transition from experimental to clinical use."," RNA Oligo, miRNA, microRNA, miRNA inhibitors, miRNA mimics, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:42:25","77,75,71,68,64","13,56",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":335,"categoryName":289,"title":336,"imgUrl":337,"content":338,"excerpt":47,"publishDate":339,"seoTitle":340,"seoDesc":341,"seoKeywords":342,"createDate":343,"sort":344,"relatedPostIds":345,"firstServiceProductId":17,"secondServiceProductIds":346,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},77,"What are the sgRNA-based pipelines currently in clinical stages?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F23_20260630155415A135.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F23_20260630155421A136.png\" title=\"sgRNA-based pipelines\" alt=\"sgRNA-based pipelines\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Single-guide RNA (sgRNA) is an essential element of CRISPR-based genome editing therapies. While sgRNA itself is not a standalone drug, it plays a pivotal role in directing Cas proteins to specific genetic sequences for precise editing. Several sgRNA-based pipelines have entered clinical trials, primarily targeting genetic disorders and certain complex diseases. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Key sgRNA-Based Clinical Pipelines \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      CRISPR Therapeutics\u002FVertex Pharmaceuticals – Exa-Cel (Exagamglogene autotemcel) \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Diseases: Sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: Uses sgRNA and Cas9 to disrupt the BCL11A gene in hematopoietic stem cells, reactivating fetal hemoglobin production. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Clinical Status: In Phase III clinical trials, with promising results; regulatory filings for approval were submitted in 2023. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Editas Medicine – EDIT-301 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Diseases: Sickle cell disease (SCD) and beta-thalassemia. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: Employs Cas12a (Cpf1) with sgRNA to precisely edit the HBG1\u002F2 promoters, increasing fetal hemoglobin expression. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Clinical Status: Phase I\u002FII trials are ongoing, with early safety and efficacy data showing encouraging outcomes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Intellia Therapeutics – NTLA-2001 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Disease: Transthyretin amyloidosis (ATTR). \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: In vivo delivery of sgRNA and Cas9 using lipid nanoparticles (LNPs) to disrupt the TTR gene, reducing toxic transthyretin protein levels. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Clinical Status: Phase I trials have demonstrated significant reductions in serum TTR levels. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Verve Therapeutics – VERVE-101 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Disease: Hypercholesterolemia. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: Uses base-editing technology guided by sgRNA to introduce specific edits into the PCSK9 gene, lowering LDL cholesterol levels. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Clinical Status: Phase I trials are underway for patients with familial hypercholesterolemia. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">     ●      Caribou Biosciences – CB-010 \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Target Disease: B-cell non-Hodgkin lymphoma. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●      Mechanism: sgRNA-based editing to enhance allogeneic CAR-T cell therapy by removing immune-evasion genes. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">          ●     Clinical Status: Phase I trials are ongoing, with preliminary data showing durable responses. \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The sgRNA-driven clinical pipeline reflects the versatility and transformative potential of CRISPR-based therapeutics. From correcting monogenic disorders to treating complex conditions like cancer and cardiovascular diseases, these therapies are steadily progressing toward commercialization. Continued innovation in sgRNA design and delivery will further expand their therapeutic reach, offering hope for previously untreatable conditions.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2025-03-13 00:00:00","RNA Synthesis & Modifications—sgRNA-based pipelines currently in clinical stages","The sgRNA-driven clinical pipeline reflects the versatility and transformative potential of CRISPR-based therapeutics. From correcting monogenic disorders to treating complex conditions like cancer and cardiovascular diseases, these therapies are steadily progressing toward commercialization.","RNA Oligo, sgRNA, guide RNA, gene editing, CRISPR, Small nucleic acid drug, custom RNA synthesis","2025-04-30 16:53:03",24,"72,68,66,64,61","58,59",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":17,"title":50,"excerpt":348,"content":349,"seoTitle":350,"seoDesc":351,"seoKeywords":352,"sort":353,"createDate":354,"secondColor":355,"showOrderPic":5,"homeState":17,"homePic":356,"homeTitle":357,"homeDesc":358,"homeSort":353,"orderDesc":359,"orderUrl":360,"email":259,"phone":260,"onlineFormUrl":360,"serviceFeatureList":8,"productServiceSubList":8},"GenCefe Biotech provides high-quality siRNA , miRNA , sgRNA , and custom RNA synthesis and modification. We can design and synthesize RNA of different lengths, different forms, and with various modifications.","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe Biotech provides high-quality \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fgencefebio.com\u002FproductsAndservices\u002F1-RNAi_Products_RNA_Synthesis.html\" style=\"font-family: Montserrat; color: rgb(0, 112, 192);\">\u003Cstrong>RNA synthesis\u003C\u002Fstrong>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> services, including siRNA, miRNA, sgRNA, and custom RNA oligonucleotide synthesis. We support both customer-designed sequences and custom RNA projects with flexible options for sequence length, modifications, and synthesis specifications. Production scales range from nmol and μmol quantities to larger-scale manufacturing, supporting diverse research and diagnostic development needs. Supported by ISO 9001 and ISO 13485 certified quality management systems, GenCefe delivers reliable RNA products, comprehensive QC documentation, and consistent project support.\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp style=\"padding: 0px; margin-top: 10px; margin-bottom: 10px; box-sizing: border-box; color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px; text-wrap-mode: wrap; background-color: rgb(255, 255, 255); line-height: 1.75em;\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px; color: rgb(54, 96, 146);\">RNA Synthesis Service Specifications:\u003C\u002Fspan>\u003Cspan style=\"color: rgb(79, 129, 189);\">\u003Cspan style=\"font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box; font-family: Montserrat; font-size: 18px;\">\u003C\u002Fspan>\u003Cspan style=\"font-size: 16px; font-family: Montserrat; font-weight: bolder; padding: 0px; margin: 0px; box-sizing: border-box;\">\u003C\u002Fspan>\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat; font-size: 16px; color: rgb(0, 0, 0);\">\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The following table summarizes our RNA synthesis service options, specifications, and ordering details:\u003C\u002Fspan>\u003C\u002Fp>\u003Ctable>\u003Ctbody style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctr class=\"firstRow\" style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Product Name\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Length\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Amount\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Purification Method\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Turnaround Time (days)*\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  background-color: rgb(31, 73, 125); border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(255, 255, 255); font-family: Montserrat; font-size: 16px;\">Order\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">RNA oligo\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">HPLC\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" rowspan=\"3\" colspan=\"1\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-width: 1px; border-style: solid; border-bottom-color: rgb(0, 0, 0); border-right-color: rgb(0, 0, 0); word-break: break-all;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Please fill out the \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo order form\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">  and send it via email to \u003C\u002Fspan>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\" style=\"background-color: transparent; text-decoration: underline; transition: 0.5s; padding: 0px; margin: 0px; box-sizing: border-box; color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">\u003Cspan style=\"color: rgb(28, 72, 127); font-family: Montserrat; font-size: 16px;\">oligo@gencefebio.com\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">.\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Modified\u002FLabeled RNA\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">nmol, to μmol\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">4-20\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003Ctr style=\"padding: 0px; margin: 0px; box-sizing: border-box;\">\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Large-scale RNA Synthesis \u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">5-100 nt\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">OD, nmol,\u003Cbr\u002F>milligram, gram\u003Cbr\u002F>level\u003C\u002Fspan>\u003C\u002Fp>\u003C\u002Ftd>\u003Ctd width=\"288\" valign=\"middle\" align=\"center\" style=\"padding: 3px 5px; margin: 0px; box-sizing: border-box; border-bottom: 1px solid #000; border-right: 1px solid #000;  border-top-width: 1px; border-left-width: 1px; border-top-style: solid; border-left-style: solid;\">\u003Cp>\u003Ca href=\"mailto:oligo@gencefebio.com\" target=\"_blank\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">Get a Quote\u003C\u002Fspan>\u003C\u002Fa>\u003C\u002Fp>\u003C\u002Ftd>\u003C\u002Ftr>\u003C\u002Ftbody>\u003C\u002Ftable>\u003Cp>\u003Cem style=\"color: rgb(68, 68, 68); font-family: "Helvetica Neue", Helvetica, Arial, -apple-system, system-ui, sans-serif; font-size: 14px;\">\u003Cspan style=\"font-family: Montserrat; font-size: 16px;\">* Turnaround time refers to the estimated time required for order processing, production, and shipment. Actual delivery times may vary depending on the destination and courier transit time.\u003C\u002Fspan>\u003C\u002Fem>\u003C\u002Fp>","RNA Synthesis | Fast Delivery & 50K+ siRNA Sets-GenCefe","GenCefe provides siRNA, miRNA, sgRNA, pegRNA, and custom RNA synthesis and modification services for RNAi, gene editing, and gene regulation.","RNA Synthesis, custom RNA oligo, RNA oligo synthesis, siRNA, miRNA, sgRNA, Antisense oligo",88,"2024-10-24 14:13:06","#48bfea","https:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2025\u002F04\u002F20\u002FRNA合成_蓝_20250420143026A002.png","RNA Synthesis","Custom synthesis and modification. 50,000+ pre-designed siRNA sets","Advance your RNA research with flexible RNA synthesis services, expert support, and dependable project execution.","https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM",[362,363,364,365,366,367,368],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":53,"parentId":17,"title":54,"subTitle":55,"excerpt":56,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":58,"parentId":17,"title":59,"subTitle":60,"excerpt":61,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":17,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":64,"parentId":17,"title":65,"subTitle":66,"excerpt":67,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":69,"parentId":17,"title":70,"subTitle":71,"excerpt":72,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":74,"parentId":17,"title":75,"subTitle":76,"excerpt":77,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":17,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":79,"parentId":17,"title":80,"subTitle":47,"excerpt":81,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":83,"parentId":17,"title":84,"subTitle":47,"excerpt":85,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},[370,371],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":53,"parentId":17,"title":54,"subTitle":55,"excerpt":56,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":18,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":58,"parentId":17,"title":59,"subTitle":60,"excerpt":61,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":17,"newState":5,"type":62,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8}]