[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"ApplicationsList":3,"BasicInfo":39,"BlogDetail47Info":51,"ProductServiceList":188},{"msg":4,"code":5,"data":6},"操作成功",0,[7,20,24,28,32,35],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":9,"title":10,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":11,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":12,"productService":8},null,9,"Oligonucleotide Drug Synthesis",90,[13,16],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":9,"orderNum":8,"ancestors":8,"id":14,"title":15,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":11,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},19,"Oligonucleotide Synthesis and Modifications",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":9,"orderNum":8,"ancestors":8,"id":17,"title":18,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":19,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},20,"Oligonucleotide biological evaluation platform",50,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":21,"title":22,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":23,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},14,"Gene&Genome Editing",80,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":25,"title":26,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":27,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},15,"Synthetic Biology",70,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":29,"title":30,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":31,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},16,"Antibody Drug Discovery",60,{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":33,"title":34,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":19,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},17,"IVD Raw Material",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"parentName":8,"parentId":5,"orderNum":8,"ancestors":8,"id":36,"title":37,"excerpt":8,"content":8,"publishDate":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"productServiceId":8,"sort":38,"homeState":8,"homePic":8,"homeTitle":8,"homeDesc":8,"homeSort":8,"applicationsSubList":8,"productService":8},18,"Vaccine and Novel Therapy",40,{"msg":4,"code":5,"data":40},{"companyName":41,"shortCompanyName":42,"title":42,"subTitle":43,"siteUrl":44,"siteDescription":45,"siteKeywords":46,"beiAnInfo":47,"email":48,"phone":49,"address":50},"GENCEFE Biotech (Wuxi, China) ","GenCefe","Your Reliable Partner of Oligo, Gene, Peptide, Protein ","https:\u002F\u002Fwww.gencefebio.com\u002F","GenCefe specializes in DNA, RNA, gene, peptide, and protein synthesis. Combined with our advanced AI-assisted design platform, we provide high-quality services for synthetic biology, molecular diagnostics, and drug discovery.","gene synthesis, oligo synthesis, RNA synthesis, DNA synthesis, peptide synthesis, protein expression and purification, gencefe, gencefe biotech","ICP备案：XXXXXXX\r\n苏公网安备32021402001785号","gene@gencefebio.com","+1 408-828-0438","17800 Castleton St, Ste 665, City of industry, CA 91748, USA",{"msg":4,"code":5,"data":52},{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":53,"categoryName":54,"title":55,"imgUrl":56,"content":57,"excerpt":58,"publishDate":59,"seoTitle":60,"seoDesc":61,"seoKeywords":62,"createDate":63,"sort":9,"relatedPostIds":64,"firstServiceProductId":65,"secondServiceProductIds":66,"relatedPost":67,"productService":128,"allSecondProductService":145,"twoSecondProductService":185},47,"Primers & Probes","What are the common types of oligonucleotide base modifications? ","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F07\u002F02\u002F3_20260702141315A202.png","\u003Cp>\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F07\u002F02\u002F3_20260702141332A203.png\" title=\"primer synthesis, base modification\" alt=\"primer synthesis, base modification\" width=\"100%\"\u002F>\u003C\u002Fp>\u003Cp>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">Oligonucleotide\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> base modification is the introduction of different chemical modifications on the bases of oligonucleotides to change their properties and functions. The following are some common types of oligonucleotide base modifications:\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.Methylation: Addition of a methyl group to nitrogen or oxygen atoms in the base. Methylation modifications can enhance oligonucleotide stability, alter DNA unwinding properties, and affect DNA-protein interactions.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.Phosphorylation: Introduction of a phosphate group onto the base. Phosphorylation modifications play important roles in biological processes such as signal transduction, gene expression regulation, and DNA repair.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3.Amination: Introduction of an amino group onto the base. Amination modifications are used in applications such as labeling primers and probes, fluorescent labeling, etc.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4.Biotinylation: Introduction of a biotin moiety onto the base. Biotinylation modifications are commonly used in oligonucleotide detection, purification, drug delivery, etc.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5.Hydroxymethylation: Introduction of a hydroxymethyl group onto the base, typically in addition to methylation modifications. Hydroxymethylation modifications play important roles in epigenetic research.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">6.Deoxyribosylation: Introduction of an acetyl group onto the sugar moiety of the base. Deoxyribosylation modifications can alter the oligonucleotide's charge properties and solubility.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">7.Locked Nucleic Acids (LNA): Introduction of a methylene bridge between the 2' and 4' positions of the sugar moiety. LNA modifications enhance the oligonucleotide's affinity and stability.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">8.Ribose Modification: Chemical modifications of the oligonucleotide's sugar moiety, such as 2'-O-methylation, 2'-O-acetylation, etc. These modifications can enhance the oligonucleotide's stability and affinity.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe provides customized \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">DNA oligo modification\u002Flabeling services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, including more than 100 modifications such as biotin, digoxigenin, phosphate, thiol, sulfhydryl, amino, special bases, and a variety of fluorescent groups. 100% of the delivered modified probes\u002Fprimers have passed mass spectrometry detection to ensure accuracy and purity, meeting the needs of scientific research and industrial-grade \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">modified primers\u002Fprobes\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","","2024-07-16 00:00:00","Oligo Synthesis—Common types of oligonucleotide base modifications","Oligonucleotide base modification is the introduction of different chemical modifications on the bases of oligonucleotides to change their properties and functions.","oligo synthesis, probe synthesis, oligo modifications, primer synthesis, base modification, modified oligo","2025-04-28 16:33:57","48,45,44,43,41",2,"62,63",[68,80,92,104,116],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":69,"categoryName":54,"title":70,"imgUrl":71,"content":72,"excerpt":58,"publishDate":73,"seoTitle":74,"seoDesc":75,"seoKeywords":76,"createDate":77,"sort":78,"relatedPostIds":79,"firstServiceProductId":65,"secondServiceProductIds":66,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},41,"What are the commonly used Oligo purification methods and which applications are they suitable for?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F07\u002F02\u002F1_20260702141111A197.png","\u003Cp>\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F07\u002F02\u002F1_20260702141150A199.png\" title=\"oligo modifications, primer synthesis\" alt=\"oligo modifications, primer synthesis\" width=\"100%\"\u002F>\u003C\u002Fp>\u003Cp>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F204.html\" style=\"font-family: Montserrat;\">\u003Cspan style=\"color: rgb(79, 129, 189);\">Oligos\u003C\u002Fspan> \u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">can be purified using various methods, each with its own advantages and suitability for different applications:\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1)  Desalting: Desalting is a simple purification method that removes small molecular weight impurities such as salts and unincorporated nucleotides. It is suitable for applications where high purity is not critical, such as some molecular biology applications like PCR amplification.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2)  Solid Phase Extraction (SPE): SPE involves binding oligos to a solid support, followed by washing to remove impurities and elution of purified oligos. It offers higher purity compared to desalting and is suitable for applications requiring higher purity, such as sequencing, cloning, and PCR.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3)  High Performance Liquid Chromatography (HPLC): HPLC separates oligos based on differences in their chemical properties, such as size, charge, and hydrophobicity. It provides high purity and is suitable for demanding applications such as oligonucleotide therapeutics, diagnostic assays, and structural studies.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4)  Polyacrylamide Gel Electrophoresis (PAGE): PAGE separates oligos based on their size by electrophoresis through a polyacrylamide gel matrix. It is often used for preparative purification of longer oligos (> 30 nucleotides) and is suitable for applications like sequencing, hybridization, and site-directed mutagenesis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5)  Reverse-phase Chromatography (RPC): RPC separates oligos based on differences in their hydrophobicity. It is particularly useful for purifying modified oligos and is suitable for applications requiring high purity, such as RNA interference studies and antisense oligonucleotide therapeutics.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">6)  Capillary Electrophoresis (CE): CE separates oligos based on differences in their charge-to-size ratio by electrophoresis through a capillary tube. It offers high resolution and is suitable for both analytical and preparative purification of oligos for various applications, including genomics, diagnostics, and gene synthesis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Each purification method has its own advantages and limitations, and the choice of method depends on factors such as the required purity, yield, length of oligos, and specific application requirements.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe’s experienced technical team has established the optimized production process and strict quality control standards. We specialize in \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F204.html\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">custom DNA oligo synthesis services \u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\"> \u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\">of various specifications and purities, supporting diverse needs such as PCR, cloning, site-directed mutagenesis, molecular diagnostics, etc.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-04-06 00:00:00","Oligo Synthesis—Oligo Purification Methods","Oligos can be purified using various methods, each with its own advantages and suitability for different applications: desalting, SPE, HPLC, PAGE, RPC, etc. ","oligo synthesis, probe synthesis, oligo modifications, primer synthesis, oligo purification, HPLC purification","2025-04-28 16:20:50",3,"52,49,46,43,42",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":81,"categoryName":54,"title":82,"imgUrl":83,"content":84,"excerpt":58,"publishDate":85,"seoTitle":86,"seoDesc":87,"seoKeywords":88,"createDate":89,"sort":90,"relatedPostIds":91,"firstServiceProductId":65,"secondServiceProductIds":66,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},43,"What are the functions of amino modification?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F07\u002F02\u002F2_20260702141223A200.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F07\u002F02\u002F2_20260702141242A201.png\" title=\"oligo modifications, primer synthesis\" alt=\"oligo modifications, primer synthesis\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Amino modifications refer to the chemical alterations that introduce amino functional groups into \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">oligonucleotides\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">. This modification can be achieved by incorporating amino groups onto the nucleobases or the sugar moieties of the oligonucleotide. Amino modifications endow oligonucleotides with specific properties and functionalities, offering numerous advantages for various biological and biotechnological applications.\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.Enhanced Stability: Amino modifications can increase the stability of oligonucleotides, making them more resistant to biological samples, such as extracellular environments, intracellular conditions, or sample processing.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.Increased Affinity: Amino modifications can enhance the binding affinity of oligonucleotides to their target molecules, thereby improving efficiency and specificity in target recognition and binding processes.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3.Improved Pharmacokinetic Properties: In nucleic acid therapeutics research, amino modifications can improve the pharmacokinetic properties of oligonucleotides, such as prolonging half-life, enhancing cellular uptake, and reducing immune responses.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4.Alteration of Charge Properties: Amino modifications can introduce charged amino groups, thereby altering the overall charge properties of oligonucleotides. This is significant for regulating migration rates and separation characteristics in techniques such as electrophoresis, gel electrophoresis, or ion-exchange chromatography.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5.Introduction of Functional Groups: Amino modifications can introduce specific functional groups onto oligonucleotides, such as amino acid residues, crosslinkers, or other biologically active moieties, thereby imparting specific biological activity or chemical reactivity.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">6.Drug Delivery and Targeting: Amino modifications can be utilized for targeted delivery of oligonucleotide therapeutics, such as by modulating their affinity for cell surface receptors to achieve targeted delivery and internalization into specific cell types.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">In summary, amino modifications provide a powerful tool for customizing the properties and functionalities of \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">oligonucleotides\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> in various biological and biotechnological fields. By modulating the type, position, and quantity of amino modifications, precise control over the properties and functions of oligonucleotides can be achieved to meet specific research or application requirements.\u003Cbr\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe provides customized \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">DNA oligo modification\u002Flabeling services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, including more than 100 modifications such as biotin, digoxigenin, phosphate, thiol, sulfhydryl, amino, special bases, and a variety of fluorescent groups. 100% of the delivered modified probes\u002Fprimers have passed mass spectrometry detection to ensure accuracy and purity, meeting the needs of scientific research and industrial-grade \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">modified primers\u002Fprobes\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-07-02 00:00:00","Oligo Synthesis—Functions of Amino Modification"," Amino modifications provide a powerful tool for customizing the properties and functionalities of oligonucleotides in various biological and biotechnological fields. By modulating the type, position, and quantity of amino modifications, precise control over the properties and functions of oligonucleotides can be achieved to meet specific research or application requirements.","oligo synthesis, probe synthesis, oligo modifications, primer synthesis, Amino modification, modified oligo","2025-04-28 16:28:47",5,"53,50,49,47,42",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":93,"categoryName":54,"title":94,"imgUrl":95,"content":96,"excerpt":58,"publishDate":97,"seoTitle":98,"seoDesc":99,"seoKeywords":100,"createDate":101,"sort":102,"relatedPostIds":103,"firstServiceProductId":65,"secondServiceProductIds":66,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},44,"What are the functions of biotin modification?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F06_20260630141858A070.jpg","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F06_20260630141905A071.jpg\" title=\"Biotin modification, modified oligo\" alt=\"Biotin modification, modified oligo\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The function of biotin modification in \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">oligonucleotides\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\"> \u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\">is primarily for affinity-based applications, particularly in molecular biology, biochemistry, and biotechnology. Biotin, a small molecule, is covalently attached to the oligonucleotide, typically at one end or at specific positions within the sequence. This modification imparts several functional advantages:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.Affinity purification: Biotin-modified oligonucleotides can be used to selectively capture or purify target molecules from complex mixtures. Biotin has a high affinity for avidin or streptavidin, proteins that bind biotin with exceptional specificity and affinity. By attaching biotin to oligonucleotides, researchers can easily isolate and purify nucleic acids, proteins, or other biomolecules that interact with the biotinylated oligo.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.Detection and quantification: Biotin-modified oligonucleotides are widely used as probes in various detection assays, such as enzyme-linked immunosorbent assays (ELISA), Southern blotting, Northern blotting, and in situ hybridization. Biotinylated oligos can bind to avidin or streptavidin conjugated to reporter molecules (e.g., enzymes, fluorophores, or nanoparticles), allowing sensitive detection and quantification of target molecules.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3.Biotin-streptavidin bridging: Biotin-modified oligonucleotides can facilitate specific interactions between different molecules by acting as a linker. For instance, biotinylated oligos can be used to bridge interactions between nucleic acids, proteins, or other biomolecules conjugated to streptavidin. This strategy is commonly employed in nucleic acid assays, protein-protein interaction studies, and biosensing applications.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4.Surface immobilization: Biotin-modified oligonucleotides can be immobilized onto solid surfaces (e.g., microarrays, beads, or plates) coated with avidin or streptavidin. This immobilization strategy enables high-density array fabrication, spatially resolved detection, and multiplexed analysis of nucleic acids, proteins, or other targets.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5.Targeted delivery: Biotin-modified oligonucleotides can be employed for targeted delivery of therapeutic agents, such as siRNA or antisense oligonucleotides. Conjugation of biotin to oligos enables specific binding to biotin receptors overexpressed on the surface of target cells, facilitating cellular uptake and enhancing the therapeutic efficacy of the cargo.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Overall, biotin modification of \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">oligonucleotides\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> offers versatile tools for a wide range of research and practical applications, enabling specific and sensitive detection, purification, and manipulation of biomolecules.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe provides customized \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">DNA oligo modification\u002Flabeling services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">,\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\"> including more than 100 modifications such as biotin, digoxigenin, phosphate, thiol, sulfhydryl, amino, special bases, and a variety of fluorescent groups. 100% of the delivered modified probes\u002Fprimers have passed mass spectrometry detection to ensure accuracy and purity, meeting the needs of scientific research and industrial-grade \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">modified primers\u002Fprobes\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-07-04 00:00:00","Oligo Synthesis—Functions of Biotin Modification","Meta Description: Biotin modification of oligonucleotides offers versatile tools for a wide range of research and practical applications, enabling specific and sensitive detection, purification, and manipulation of biomolecules."," oligo synthesis, probe synthesis, oligo modifications, primer synthesis, Biotin modification, modified oligo","2025-04-28 16:30:04",6,"53,51,49,47,45",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":105,"categoryName":54,"title":106,"imgUrl":107,"content":108,"excerpt":58,"publishDate":109,"seoTitle":110,"seoDesc":111,"seoKeywords":112,"createDate":113,"sort":114,"relatedPostIds":115,"firstServiceProductId":65,"secondServiceProductIds":66,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},45,"What are the functions of Digoxigenin modification?","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F07_20260630142007A072.jpg","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F06\u002F30\u002F07_20260630142015A073.jpg\" title=\" Digoxigenin modification, modified oligo\" alt=\" Digoxigenin modification, modified oligo\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">The digoxigenin modification involves attaching digoxigenin molecules to \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">oligonucleotides\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">. Digoxigenin is a naturally occurring plant compound with strong affinity, capable of forming stable complexes with anti-digoxigenin antibodies. This modification finds several applications in molecular biology and biochemistry, with the following functions:\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.Probe labeling: Digoxigenin-modified oligonucleotides serve as molecular probes for detecting the presence and localization of target molecules in various detection and analysis techniques. By incorporating digoxigenin labels into oligonucleotide sequences, target molecules can be detected through binding with anti-digoxigenin antibodies.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.In situ hybridization: Digoxigenin-modified oligonucleotides are commonly used in in situ hybridization experiments to detect and localize specific nucleic acid sequences in cellular or tissue samples. Visualizing target nucleic acid sequences is achieved through binding with anti-digoxigenin antibodies.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3.Immunoassays: Digoxigenin-modified oligonucleotides find utility in various immunoassay techniques, such as enzyme-linked immunosorbent assays (ELISA) or Western blotting. Binding with anti-digoxigenin antibodies enables quantitative detection and analysis of target molecules.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4.Drug delivery and targeting: Digoxigenin-modified oligonucleotides can also be used for drug delivery and targeted therapy. Incorporating digoxigenin labels into oligonucleotide drugs enables targeted delivery to specific cell types, thereby enhancing drug efficacy and reducing side effects.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5.DNA probes and primers: Digoxigenin-modified oligonucleotides serve as DNA probes or primers in applications such as polymerase chain reaction (PCR), DNA hybridization, and DNA sequencing. Digoxigenin labeling confers specific functionalities and applications to oligonucleotides in these techniques.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Digoxigenin-modified \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">oligonucleotides\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\"> have widespread applications in life science research, including molecular diagnostics, gene expression analysis, drug development, etc., providing researchers with a powerful tool for studying and understanding biological processes.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe provides customized \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">DNA oligo modification\u002Flabeling services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, including more than 100 modifications such as biotin, digoxigenin, phosphate, thiol, sulfhydryl, amino, special bases, and a variety of fluorescent groups. 100% of the delivered modified probes\u002Fprimers have passed mass spectrometry detection to ensure accuracy and purity, meeting the needs of scientific research and industrial-grade \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">modified primers\u002Fprobes\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-07-09 00:00:00","Oligo Synthesis—Functions of Digoxigenin Modification","Digoxigenin-modified oligonucleotides have widespread applications in life science research, including molecular diagnostics, gene expression analysis, drug development, etc., providing researchers with a powerful tool for studying and understanding biological processes.","oligo synthesis, probe synthesis, oligo modifications, primer synthesis, Digoxigenin modification, modified oligo","2025-04-28 16:31:46",7,"52,51,48,47,43",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":117,"categoryName":54,"title":118,"imgUrl":119,"content":120,"excerpt":58,"publishDate":121,"seoTitle":122,"seoDesc":123,"seoKeywords":124,"createDate":125,"sort":126,"relatedPostIds":127,"firstServiceProductId":65,"secondServiceProductIds":66,"relatedPost":8,"productService":8,"allSecondProductService":8,"twoSecondProductService":8},48,"What are the functions of Locked Nucleic Acid (LNA) modification? ","http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F07\u002F02\u002F4_20260702141401A204.png","\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">\u003Cimg src=\"http:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2026\u002F07\u002F02\u002F4_20260702141416A205.png\" title=\"primer synthesis, LNA modification\" alt=\"primer synthesis, LNA modification\" width=\"100%\"\u002F>\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Locked Nucleic Acid (LNA) modification refers to the introduction of a methylene bridge between the 2' oxygen and 4' carbon of the ribose sugar in the nucleotide backbone. This modification confers several advantageous properties to \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">oligonucleotides\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, leading to various applications in molecular biology and biotechnology. Here are some key functions and effects of LNA modification:\u003C\u002Fspan>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">1.Increased Thermal Stability: LNA-modified oligonucleotides exhibit significantly enhanced thermal stability compared to unmodified oligos. The locked conformation of the sugar-phosphate backbone prevents the formation of the 3' endo conformer, resulting in stronger base stacking interactions and improved duplex stability. This makes LNA probes and primers highly suitable for applications requiring stringent hybridization conditions, such as PCR, SNP genotyping, and in situ hybridization.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">2.Enhanced Specificity: The increased thermal stability of LNA-modified oligonucleotides leads to enhanced specificity in target binding. LNA probes and primers demonstrate reduced propensity for non-specific hybridization and off-target binding, resulting in improved discrimination between closely related sequences. This is particularly beneficial for applications requiring high specificity, such as mutation detection and SNP analysis.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">3.Improved Sensitivity: LNA modification enhances the sensitivity of oligonucleotide-based detection assays. The improved stability and specificity of LNA probes enable the detection of low-abundance targets with high sensitivity and accuracy. LNA probes are widely used in fluorescence in situ hybridization (FISH), real-time PCR, and other nucleic acid detection techniques to achieve sensitive and reliable detection of nucleic acid targets.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">4.Increased Nuclease Resistance: LNA modification confers increased resistance to nuclease degradation, prolonging the half-life of LNA-modified oligonucleotides in biological fluids and cellular environments. This enhanced stability enhances the efficacy of LNA oligos in applications such as RNA interference (RNAi), antisense therapy, and gene silencing, where oligonucleotides need to resist enzymatic degradation for prolonged activity.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">5.Facilitated SNP Discrimination: LNA probes are highly effective for single nucleotide polymorphism (SNP) genotyping due to their enhanced specificity and discrimination capabilities. The increased stability and binding affinity of LNA probes enable accurate discrimination between single nucleotide differences, making them valuable tools for SNP detection and analysis in research and clinical diagnostics.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">Overall, LNA modification enhances the stability, specificity, sensitivity, and nuclease resistance of \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F11.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">oligonucleotides\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">,\u003C\u002Fspan>\u003Cspan style=\"font-family: Montserrat;\"> making them versatile tools for a wide range of applications in molecular biology, diagnostics, and therapeutics.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: Montserrat;\">GenCefe provides customized \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">DNA oligo modification\u002Flabeling services\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat;\">, including more than 100 modifications such as biotin, digoxigenin, phosphate, thiol, sulfhydryl, amino, special bases, and a variety of fluorescent groups. 100% of the delivered modified probes\u002Fprimers have passed mass spectrometry detection to ensure accuracy and purity, meeting the needs of scientific research and industrial-grade \u003C\u002Fspan>\u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FOligoSynthesis\u002F23.html\" target=\"_blank\" style=\"text-decoration: underline; font-family: Montserrat; color: rgb(79, 129, 189);\">\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">modified primers\u002Fprobes\u003C\u002Fspan>\u003C\u002Fa>\u003Cspan style=\"font-family: Montserrat; color: rgb(79, 129, 189);\">.\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cbr\u002F>\u003C\u002Fp>","2024-07-18 00:00:00","Oligo Synthesis—Locked Nucleic Acid (LNA) modification","LNA modification enhances the stability, specificity, sensitivity, and nuclease resistance of oligonucleotides, making them versatile tools for a wide range of applications in molecular biology, diagnostics, and therapeutics.","oligo synthesis, probe synthesis, oligo modifications, primer synthesis, LNA modification, modified oligo, Locked Nucleic Acid","2025-04-28 16:34:58",10,"52,50,49,47,46",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":65,"title":129,"excerpt":130,"content":131,"seoTitle":132,"seoDesc":133,"seoKeywords":134,"sort":135,"createDate":136,"secondColor":137,"showOrderPic":5,"homeState":138,"homePic":139,"homeTitle":140,"homeDesc":141,"homeSort":135,"orderDesc":142,"orderUrl":143,"email":144,"phone":49,"onlineFormUrl":143,"serviceFeatureList":8,"productServiceSubList":8},"DNA Oligo Synthesis","GenCefe offers high-quality DNA oligo synthesis, including standard primers, modified oligos, qPCR\u002FNGS primers and probes, with reliable performance for diverse research needs.","\u003Cp style=\"line-height: 1.75em;\">\u003Cspan style=\"font-family: Montserrat;\">\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>GenCefe provides high-quality DNA \u003Ca href=\"https:\u002F\u002Fwww.gencefebio.com\u002FproductsAndservices\u002F2-DNA_Oligo_Synthesis.html\" style=\"text-decoration: underline; color: rgb(0, 112, 192);\">\u003Cspan style=\"color: rgb(0, 112, 192);\">\u003Cstrong>oligo synthesis\u003C\u002Fstrong>\u003C\u002Fspan>\u003C\u002Fa> and modification services, including standard DNA primers, modified DNA oligos, qPCR primers and probes, and NGS primers and probes. Our DNA oligo synthesis services are supported by standardized production workflows and strict quality control to ensure high consistency, accuracy, and reliable performance across research and in vitro applications.\u003C\u002Fp>\u003Cp style=\"line-height: 1.75em;\">\u003Cspan style=\"font-family: Montserrat;\">\u003C\u002Fspan>\u003C\u002Fp>","DNA Synthesis | Fast Delivery & Reliable Quality-GenCefe","GenCefe provides DNA oligo synthesis services, including standard primers, modified oligos, and qPCR primers and probes for research and IVD applications.","DNA synthesis, DNA oligo synthesis, Custom DNA synthesis, Custom DNA oligo synthesis, DNA oligo, Primer synthesis, Probe synthesis",77,"2024-10-24 15:41:04","#185192",1,"https:\u002F\u002Fmanage.gencefebio.com\u002Fprofile\u002Fupload\u002F2025\u002F04\u002F20\u002FDNA_蓝_20250420143200A003.png","DNA Synthesis","High-quality primers and probes for research and industrial use","Get high-quality DNA oligos with reliable performance, flexible customization, and efficient delivery—submit your sequence to start your project with GenCefe.","https:\u002F\u002Fforms.zohopublic.com\u002Fgencefebiotech\u002Fform\u002FRNAsynthesisQuoteForm\u002Fformperma\u002FIYj3YS_MNOP-_4ozkpMtj2ONDpoS9eqBGWF3bBvb2xM","oligo@gencefebio.com",[146,152,156,161,165,169,173,178,181],{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":147,"parentId":65,"title":148,"subTitle":149,"excerpt":150,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":151,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},62,"Custom DNA Oligo Synthesis","Custom DNA Oligo Synthesis with Flexible Specifications and Reliable Quality","GenCefe provides high-quality oligonucleotide synthesis and modification services, including standard primers, qPCR primers and probes, NGS primers, etc. ","服务",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":153,"parentId":65,"title":154,"subTitle":58,"excerpt":155,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":151,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},63,"DNA Oligo Modifications","GenCefe provides comprehensive modifications, including biotin, digoxigenin, fluorescence, phosphorylation, phosphorothioates, amino Linkers, etc.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":157,"parentId":65,"title":158,"subTitle":159,"excerpt":160,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":151,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},64,"qPCR Primers & Probes","Custom qPCR primers and probes with flexible specifications and reliable quality.","GenCefe Biotech has established an advanced oligo synthesis and modification technology platform with an experienced technical team to provide customized qPCR primers and probes.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":162,"parentId":65,"title":163,"subTitle":58,"excerpt":164,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":151,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},65,"NGS Primers & Probes","GenCefe Biotech offers NGS adapters, blockers, capture probes, and multiplex PCR primers using advanced oligo synthesis and modification technology.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":166,"parentId":65,"title":167,"subTitle":58,"excerpt":168,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":151,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},66,"FISH Probes","GenCefe Biotech offers custom FISH probe design and synthesis with various fluorescent labels (Cy3, Cy5, FAM), HPLC purification, and expert technical support.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":170,"parentId":65,"title":171,"subTitle":58,"excerpt":172,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":151,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},67,"STR Primers"," GenCefe offers high-quality fluorescently labeled STR primers for forensic applications, with optimized dyes, purification processes, and strict quality standards.",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":174,"parentId":65,"title":175,"subTitle":176,"excerpt":177,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":138,"type":151,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},68,"Circular DNA","Custom single-stranded circular DNA synthesis tailored to your research needs. ","GenCefe Biotech has successfully developed single-stranded circular DNA (CssDNA) synthesis technology, providing researchers in gene expression, gene therapy, and vaccine development with a powerful new tool. ",{"createBy":8,"createTime":8,"updateBy":8,"updateTime":8,"remark":8,"id":27,"parentId":65,"title":179,"subTitle":58,"excerpt":180,"content":8,"seoTitle":8,"seoDesc":8,"seoKeywords":8,"createDate":8,"orderDesc":8,"orderUrl":8,"email":8,"phone":8,"onlineFormUrl":8,"sort":8,"hotState":5,"newState":5,"type":151,"customerTestimonials":8,"productCatalog":8,"relatedTitles":8,"productService":8,"customerTestimonialsList":8,"relatedTitlesList":8,"serviceFeatureSubList":8,"productCatalogList":8},"PCR Assay Design and Development","GenCefe Biotech combines 10+ years oligo synthesis experience with bioinformatics and AI to offer one-step PCR assay design, synthesis, and verification 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