Several delivery strategies are employed to overcome the challenges of nucleic acid stability, cellular uptake, and tissue targeting for small nucleic acid drugs. 

     ●      Liposomes and Lipid Nanoparticles (LNPs): Encapsulate nucleic acids in lipid-based carriers to improve stability and facilitate cell membrane fusion for delivery. 

     ●      Polymeric Nanoparticles: Utilize biocompatible polymers (e.g., polyethyleneimine, chitosan) to form nanoparticles that protect nucleic acids and enhance cellular uptake. 

     ●      Viral Vectors: Modified viruses (e.g., adenoviruses, lentiviruses) are used to deliver nucleic acids, ensuring efficient gene transfer. 

     ●      Exosome-Based Delivery: Use natural exosomes as carriers to facilitate targeted delivery and immune evasion. 

     ●      Cationic Lipid and Polymers: These positively charged molecules bind to negatively charged nucleic acids, enhancing delivery and uptake by cells. 

     ●      Targeted Delivery Systems: Surface modifications (e.g., antibodies, peptides) on delivery vehicles to selectively target specific cells or tissues. 

These strategies focus on improving the bioavailability, targeting, and cellular uptake of small nucleic acid drugs for effective therapy. 

GenCefe Biotech provides high-quality siRNA, miRNA, sgRNA, and custom RNA synthesis services. We can design and synthesize RNA Oligos of different lengths, different forms, and with various modifications according to customer’s needs, and also synthesize RNA sequences designed by customers. The RNA products we deliver are all purified by HPLC. ISO 9001-certified facilities and comprehensive quality control reports ensure the delivery of high-quality products.