Stable Isotope-Labeled Peptides

Isotope-labeled peptides are commonly used in proteomics research and peptide metabolic pathway research. Generally, stable isotopes N15 and C13 are used for labeling, and mass analysis instruments such as mass spectrometer, gas chromatograph, and nuclear magnetic resonance are used for measurement.

GenCefe provides custom stable isotope-labeled peptides, which directly introduces amino acids labeled with isotopes, such as C, N, during the peptide synthesis process to achieve the purpose of labeling the entire peptide chain. Commonly used isotope-labeled amino acids include alanine (Ala), lysine (Lys), arginine (Arg), etc.

Service Types

● N15-labeled isotope peptides

● C13-labeled isotope peptides

● N15, C13 dual-labeled isotope peptides

Case Studies

[D10]Leu-Insulin (Human) (+40 Da)

[13C18,15N3]-Hepcidin (Human) (+21 Da)

Isotope Types

Amino acid	Code	Mass difference	Isotope	Isotopic enrichment
Alanine	A	+4 Da	U-13C3, 15N	>99%
Arginine	R	+10 Da	U-13C6, 15N4	>99%
Isoleucine	I	+7 Da	U-13C6, 15N	>99%
Leucine	L	+7 Da	U-13C6, 15N4	>99%
Lysine	K	+8 Da	U-13C6, 15N2	>99%
Phenylalanine	F	+10 Da	U-13C9, 15N	>99%
Proline	P	+6 Da	U-13C5, 15N	>99%
Valine	V	+6 Da	U-13C5, 15N	>99%

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